Abstract
A series of 6-[N-(halophenyl)amino]-7-chloro-5,8-quinolinedione derivatives 1–10 were tested for antifungal susceptibilities,in vitro, against pathogenicCandida species such asC. albicans, C. glabrata, C. krusei, C. parapsilosis andC. tropicalis. The MICs were determined by the standard macrodilution techniques, according to the NCCLS 1992 guidelines. The 6-[N-(halophenyl)amino]-7-chloro-5,8-quinolinedione derivatives showed generally potent antifungal activities against pathogenicCandida species. Among them, derivative1, 2, 5 and7 showed more potent antifungal activities than ketoconazole. All derivatives1–10 had specially potent activities againstC. tropicalis. Derivative1 and2 containing (N-3,4-dihalo-phenyl)amino moiety exhibited the potent antifungal activities. Derivative2 with (3,4-dichlorophenyl)amino substituent was the most effective in preventing the growth ofCandida species at MICs 4 μg/ml respectively.
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Ryu, CK., Kim, DH. The antifungal activities of some 6-[N-(halophenyl)amino]-7-chloro-5,8-quinolinediones againstCandida species. Arch. Pharm. Res. 17, 483–486 (1994). https://doi.org/10.1007/BF02979131
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DOI: https://doi.org/10.1007/BF02979131