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Gastroprotective and antioxidant effects of amiodarone on indomethacin-induced gastric ulcers in rats

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  • Drug efficacy and safety
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Abstract

Reactive oxygen species (ROS) have been implicated in the etiology of indomethacin-induced gastric mucosal damage. This study investigated amiodarone’s protective effects against oxidative gastric mucosal damage induced by indomethacin. Amiodarone is a widely used antiarrhythmic agent. We have investigated alterations in the glutathione level, and the activities of antioxidative enzymes [superoxide dismutase, catalase, glutathione s-transferase glutathione reductase and myeloperoxidase], as markers for ulceration process following oral administration of amiodarone and ranitidine in rats with indomethacin-induced ulcers. In the present study we found that 1) amiodarone, lansoprazole and ranitidine reduced the development of indomethacin-induced gastric damages, at a greater magnitude for amiodarone and lansoprazole than for ranitidine; 2) amiodarone and ranitidine alleviated increases in the activities of catalase and glutathione s-transferase enzymes resulting from ulcers; 3) amiodarone and ranitidine ameliorated depressions in the glutathione level and the activities of superoxide dismutase and glutathione reductase enzymes caused by indomethacin administration; and 4) all doses of amiodarone amplified the myeloperoxidase activity resulting from indomethacin-induced gastric ulcers. The results indicate that the gastroprotective activity of amiodarone, which may be linked to its intrinsic antioxidant properties, cannot be attributed to its effect on myeloperoxidase activity.

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Authors and Affiliations

  1. Faculty of Pharmacy, Department of Biochemistry, Ataturk University, 25240, Erzurum, Turkey

    F. Odabasoglu & Y Bayir

  2. Faculty of Medicine, Department of Pharmacology, Ataturk University, 25240, Erzurum, Turkey

    Z Halici, H Suleyman & E Cadirci

  3. Faculty of Medicine, Department of Pharmacology, Karaelmas University, Zonguldak, Turkey

    G Ozbakis Dengiz

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  1. G Ozbakis Dengiz
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  2. F. Odabasoglu
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  3. Z Halici
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  4. H Suleyman
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  5. E Cadirci
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  6. Y Bayir
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Correspondence to Z Halici.

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Dengiz, G.O., Odabasoglu, F., Halici, Z. et al. Gastroprotective and antioxidant effects of amiodarone on indomethacin-induced gastric ulcers in rats. Arch Pharm Res 30, 1426–1434 (2007). https://doi.org/10.1007/BF02977367

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  • DOI: https://doi.org/10.1007/BF02977367

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