Abstract
The Hantzsh reaction of 7-hydroxy-8-methoxy-2-oxo-2H-1-benzopyran-6-carboxaldehyde (1) with ethyl acetoacetate and ammonia yields the dihydropyridine derivative 2 together with the pyridine derivative 3 and the eight membred ring derivative 4. Reaction of 1 with ethyl cyanoacetate and malononitrile gives the iminodicoumarin derivatives 5 and 6 respectiely. The latter compound was reacted with butan-2-one and acetophenone to produce the Michael adduct 7a, b and the 2-aminopyridine derivatives 8a, b.
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El-Diwani, H.I. Synthesis of some pyridine and dihydropyridine derivatives from 7-hydroxy-8-methoxy-2-oxo-2H-1-benzopyran-6-carboxaldehyde. Arch. Pharm. Res. 18, 27–30 (1995). https://doi.org/10.1007/BF02976503
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DOI: https://doi.org/10.1007/BF02976503