Skip to main content
SpringerLink
Log in

Antidiabetic coumarin and cyclitol compounds fromPeucedanum japonicum

  • Research Article
  • Article
  • Published:
Archives of Pharmacal Research Aims and scope Submit manuscript

Abstract

The antidiabetic activity-guided fractionation and isolation of the 80% EtOH extracts from Peucedani Radix(Peucedanum japonicum, Umbelliferae) led to the isolation and characterization of a coumarin and a cyclitol as active principles, that is, peucedanol 7-O-β-D-glucopyranoside (1) and myo-inositol (2). Their structures were identified by spectroscopic methods. Compound1 showed 39% inhibition of postprandial hyperglycemia at 5.8 mg/kg dose, and compound2 also significantly inhibited postprandial hyperglycemia by 34% (P<0.05).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Attels, A. S., Zhou, Y. P., Xie, J. T., Wu, J. A., Zhang, L., and Dey, L., Antidiabetic effects ofPanax ginseng berry extract and the identification of an effective component.Diabetes, 51, 1851–1858 (2002).

    Article  Google Scholar 

  • Bae, K. H., The medicinal plants of Korea. Kyohaksa, Seoul, Korea, p.380, (2001).

    Google Scholar 

  • Chen, I. S., Chang, C. T., Sheen, W. S., Teng, C. M., Tsai, I. L., Duh, C. Y., and Ko, F. N., Coumarins and antiplatelet aggregation constituents from formosanPeucedanum japonicum.Phytochemistry, 41, 525–530 (1996).

    Article  PubMed  CAS  Google Scholar 

  • Ikeshiro, Y., Mase, I., and Tomita, Y., Coumarin glycosides fromPeucedanum japonicum.Phytochemistry, 35, 1339–1341 (1994).

    PubMed  CAS  Google Scholar 

  • Loewus, F. A. and Murthy, P. P. N., myo-Inositol metabolism in plants.Plant. Sci., 150, 1–19 (2000).

    Article  CAS  Google Scholar 

  • Trinder, P., Determination of blood glucose using an oxidaseperoxidase system with a non-carcinogenic chromogen.J. Clin. Pathol., 22, 158–161, (1969)

    Article  PubMed  CAS  Google Scholar 

  • Xie, J. T., Aung, H. H., Wu, J. A., Attele, A. S., and Yuan, C. S., Effects of American ginseng berry extract on blood glucose levels in ob/ob mice.Am. J. Chin. Med., 30, 187–194 (2002).

    Article  PubMed  Google Scholar 

  • Yoo, S. W., Kim, J. S., Kang, S. S., Son K. H., Chang H. W., Kim, H. P., Bae, K. H., and Lee, C. O., Constituents of the fruits and leaves ofEuodia daniellii.Arch. Pharm. Res., 25, 824–830 (2002).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pharmacology Lab, College of Pharmacy, Kyung Hee University, 130-701, Seoul, Korea

    Sung Hyun Chung & Sang Hyun Park

  2. Natural products Project, R&D Center of Pharmaceuticals of Science & Technology, Ichon-Si, Gyeonggi-Do, 467-812, Korea

    Hee Chol Kang, Eun Young Yang & Hi Jae Cho

  3. Natural Products Laboratory, College of Pharmacy, SungKyunKwan University, 300 Chonchondong, 440-746, Jangan-ku, Gyeonggi-Do, Suwon, Korea

    Sung Ok Lee, Sang Zin Choi, Jong Hwa Lee, Sung Hyun Chung, Sang Hyun Park, Hee Chol Kang, Eun Young Yang, Hi Jae Cho & Kang Ro Lee

Authors
  1. Sung Ok Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sang Zin Choi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jong Hwa Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sung Hyun Chung
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Sang Hyun Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hee Chol Kang
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Eun Young Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Hi Jae Cho
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Kang Ro Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kang Ro Lee.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lee, S.O., Choi, S.Z., Lee, J.H. et al. Antidiabetic coumarin and cyclitol compounds fromPeucedanum japonicum . Arch Pharm Res 27, 1207–1210 (2004). https://doi.org/10.1007/BF02975882

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02975882

Keywords

Search

Navigation