Abstract
Circadian variations of sulfamethoxazole pharmacokinetics were studied after a single oral administration of sulfamethoxazole, 50 mg/kg, to rabbits at 09:00 (a.m.) and 22:00 (p.m.). The profiles of plasma sulfamethoxazole concentration showed from 6h to 24 h significant statistical difference (p<0.05) between 09:00 and 22:00. The half-life (t1/2) was significantly shorter in the morning (11.2 ± 3.2 h) when compared to the nighttime (15.4 ±3.5 h) (p< 0.05). The AUC was significantly decreased in the morning (1325 ± 264 μg/ml-h) than that in the nighttime (2059 ± 379 μg/ml-h) (p<0.05). Total body clearance (CL1) was significantly higher when sulfamethoxazole was given in the morning (6.65 ± 0.23 ml/min) versus in the nighttime (4.28 ± 0.20 ml/min) (p<0.05).
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Choi, J.S., Jung, E.J. Circadian changes in Pharmacokinetics of Sulfamethoxazole administered orally to rabbits. Arch Pharm Res 24, 338–341 (2001). https://doi.org/10.1007/BF02975103
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DOI: https://doi.org/10.1007/BF02975103