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Effects of n-Alkanols on the lateral diffusion of total phospholipid fraction extracted from brain membranes

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Abstract

We investigated the effects ofn-alkanols on the range and rate of the lateral diffusion of 1,3-di(1-pyrenyl)propane in the model membranes of total phospholipid fraction extracted from synaptosomal plasma membrane vesicles. n-Alkanols increased the range and rate of the lateral diffusion of 1,3-di(1-pyrenyl)propane in the bulk model membrane structures (inner+outer monolayers) and the potencies ofn-alkanols up to 1-nonanol increased by 1 order of magnitude as the carbon chain length increases by two carbon atoms. The cut-off phenomenon was reached at 1-decanol, where further increase in hydrocarbon length resulted in a decrease in the lateral diffusion. However, significant changes in the l′/l value were not observed by methanol (from 100 to 2500 mM), ethanol (from 25 to 800 mM), and 1-propanol (from 10 to 250 mM) over entire concentration.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery and Clinical Pharmacology Unit, College of Dentistry and Research Institute for Oral Biotechnology, Pusan National University, 602-739, Pusan, Korea

    In-Kyo Chung

  2. Department of Oral Biochemistry and Molecular Biology, College of Dentistry and Research Institute for Oral Biotechnology, Pusan National University, 602-739, Pusan, Korea

    Jung-Sook Kang

  3. Department of Dental Pharmacology and Biophysics, College of Dentistry and Research Institute for Oral Biotechnology, Pusan National University, 602-739, Pusan, Korea

    Il Yun

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  1. In-Kyo Chung
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  2. Jung-Sook Kang
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Chung, IK., Kang, JS. & Yun, I. Effects of n-Alkanols on the lateral diffusion of total phospholipid fraction extracted from brain membranes. Arch. Pharm. Res. 16, 191–195 (1993). https://doi.org/10.1007/BF02974481

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