Abstract
Four xanthones were isolated from mycelia ofEmericella variecolor, an endophytic fungus isolated from the leaves ofCroton oblongifolius. Their structures were elucidated by spectroscopic analysis to be shamixanthone, 14-methoxytajixanthone-25-acetate, tajixanthone methanoate, and tajixanthone hydrate. All compounds were tested for cytotoxic activity against various human tumor cell lines including gastric carcinoma, colon carcinoma, breast carcinoma, human hepatocarcinoma, and lung carcinoma. The antitumor activities of these xanthones were compared with that of doxorubicin hydrochloride, a chemotherapeutic substance. All of them showed moderate activities and were selective against gastric carcinoma, colon carcinoma, and breast carcinoma. Only tajixanthone hydrate exhibited moderate activity against all cancer cell lines. Furthermore, under the test conditions it was found that 14-methoxytajixanthone-25-acetate and tajixanthone hydrate are almost as active as doxorubicin hydrochloride against gastric carcinoma (KATO3) and breast carcinoma (BT474).
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Pornpakakul, S., Liangsakul, J., Ngamrojanavanich, N. et al. Cytotoxic activity fo four xanthones fromEmericella variecolor, an endophytic fungus isolated fromCroton oblongifolius . Arch Pharm Res 29, 140–144 (2006). https://doi.org/10.1007/BF02974275
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DOI: https://doi.org/10.1007/BF02974275