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Antitumor activity of stilbenoids and flavonoids isolated from Acanthopanax brachypus

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Abstract

This report is the first to detail the antitumor activity of Acanthopanax brachypus, a species well recognized by eastern folk medicine. Four stilbeniods and nine flavonoids have been isolated from stem bark of the plant. The isolates have been tested for their antitumor activity against selected human cancer cell lines (HgpG-2, MCF-7, K-562, and A-549). Even though three of the compounds have shown high to moderate cytotoxicity against certain cell lines (IC50 of 4.5 to 6.5 μg/mL), in most of the experiments little or no anticancer activity has been revealed.

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Authors and Affiliations

  1. College of Chemistry and Chemical Engineering, Longdong University, No. 45, Lanzhou East Road, Qingyang City, Gansu Province, People’s Republic of China

    Hao-bin Hu, Xiao-wei Zhang & Yun Wu

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  1. Hao-bin Hu
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  2. Xiao-wei Zhang
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  3. Yun Wu
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Correspondence to Hao-bin Hu.

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The text was submitted by the authors in English.

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Hu, Hb., Zhang, Xw. & Wu, Y. Antitumor activity of stilbenoids and flavonoids isolated from Acanthopanax brachypus . Russ J Gen Chem 84, 1434–1441 (2014). https://doi.org/10.1134/S1070363214070329

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  • DOI: https://doi.org/10.1134/S1070363214070329

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