Abstract
A new compound 2 and two known guaiane-type sesquiterpenoids were isolated from the methylene chloride-soluble fraction of the methanolic extract of the fruits ofTorilis japonica (Umbelliferae) through repeated silica gel and Sephadex LH-20 column chromatography. Their chemical structures were elucidated as torilin (1), 11-acetoxy-8-angeloyloxy-1β-hydroxy-4-guaien-3-one (1β-hydroxytorilin,2) and 11-acetoxy-8-angeloyloxy-1α-hydroxy-4-guaien-3-one (1α-hydroxytorilin,3) by spectroscopic analysis. Compounds1–3 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells.
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Park, H.W., Choi, SU., Baek, NI. et al. Guaiane sesquiterpenoids fromTorilis japonica and their cytotoxic effects on human cancer cell lines. Arch Pharm Res 29, 131–134 (2006). https://doi.org/10.1007/BF02974273
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DOI: https://doi.org/10.1007/BF02974273