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Ketoketene gem-dithiols: Synthesis of some sulphur heterocycles as antimicrobial agents

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Abstract

A convenient method for the preparation of N-aryl thiazolines4a,b, 2,2-dichlorothiophene5, thiazolinones6 and8, and 2,6-dihydrothiopyran 2-thione9 derivatives is described. This depends on interaction of 3,3-dimercapto-1-(4-biphenyl)-2-propen-1-one1 with dichloroethane, amines, trichloroacetylchloride, chloroacetamide, ethylene oxide and epichlorohydrin. Antimicrobial activity of the obtained products was studied.

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Literature Cited

  1. Misra, V. S. and Husin, I.: Possible antitubercolotic compounds. X, 2-thiazolyl and 6-benzimidazolyl amidines.J. Indian Chem. Soc.,37, 710 (1960).

    CAS  Google Scholar 

  2. Youssef, K. M. and Elmeligie, S.: Novel 2-mercaptobenzothiazole derivatives, synthesis and antimicrobial activity.Egypt. J. Pharm. Sci.,30, 1–4; 455. 1989.

    CAS  Google Scholar 

  3. Takada, S., Shindo, H., Sasatani, T., Chomei, N., Matsuchita, A., Eigyo, M., Kawasaki, K., Murata, S., Takahara, Y. and Shinkaku, H.: Thienylpyrazoloquinolines; Potent agonistis and inverse agonists to benzodiazepine receptors.J. Med. Chem. 31, 1738 (1988).

    Article  PubMed  CAS  Google Scholar 

  4. Kambe, S. and Saito, K.: A simplified procedure for the preparation of alkoxycarbonyl 5-aryl 4-cyano-3-hydroxy 3-phenyltetrahydrothiophenes.Synthesis, 839 (1980).

  5. Meislich, H.: “Pyridine and its derivatives”, Klinsbery, K. Ed.Interscience, New York (1962).

    Google Scholar 

  6. Augustein, M., Jahreis, G. and Rudorf, W. D.: Synthesis offenkettiger und cyclischer Katenheteroacetale aus ungesättigten B-ketonitrilen;Synthesis, 472 (1977).

  7. Elnagdi, M. H., Elmoghayar, M. R. H. and Elgemeie, G. H.: Chemistry of 3-oxoalkanenitriles.Synthesis 21 (1984).

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Authors and Affiliations

  1. Faculty of Science, Qena, Assiut University, Qena, A.R. Egypt

    Salem E. Zayed

  2. National Organization for Drug Control and Research, Egypt

    Ibrahim A. Hussin

Authors
  1. Salem E. Zayed
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  2. Ibrahim A. Hussin
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Zayed, S.E., Hussin, I.A. Ketoketene gem-dithiols: Synthesis of some sulphur heterocycles as antimicrobial agents. Arch. Pharm. Res. 15, 91–94 (1992). https://doi.org/10.1007/BF02973991

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  • DOI: https://doi.org/10.1007/BF02973991

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