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Valuation of the anti-inflammatory activity of a new drug on the gastroduodenal and rectal mucosa

  • Published:
Acta Endoscopica

Summary

The excellent tolerance and the effective anti-inflammatory, antiedema activity of a new synthetic compound, 2-phenyl-4 p. chlorophenyl-thiazol-5-ylacetic acid (Norvedan) has been demonstrated by endoscopic examination.

Resume

L’activité anti-inflammatoire d’une nouvelle molécule synthétique (2-phényl-4 p. chlorophényl — thiazol — 5 — ylacetic acid — Norvedan) a été testée sur la muqueuse gastro-duodénale et rectale par des examens endoscopiques. Les résultats sur une série de 56 patients ont été tout à fait satisfaisants. La tolérance de ce médicament est considérée comme excellente. Les examens fibroscopiques de contrôle n’ont précisé aucune anomalie muqueuse telle qu’on peut en voir après traitement anti-inflammatoire habituel (salicyclés...). Par ailleurs, ces examens ont montré l’effet anti-inflammatoire, l’activité anti-oedémateuse au niveau de la muqueuse gastrique.

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References

  1. MARMO E., ROSSI F., DI NOLA R., SPADARO R., CAZZOLA M.: «Ricerche sperimentali sull’acido 2-fenil-4 p. clorofenil-tiazol-5-ilacetico, farmaco ad attività antireazionale, antidolorifica ed antipiretica (BR 700)».Gazz. Med. It. in course of publication.

  2. ROSSI F., DI NOLA R., CAZZOLA M.: «Valutazione del l’attività antireazionale antipiretica ed antidolorifica del BR 700, somministrato per via rettale».Gazz. Med. It. in course of publication.

  3. MARMO E., ROSSI F., DI NOLA R., GOMARASCA P.: «Inda gini farmacocinesiche sul BR 700, farmaco ad attività antireazionale, antidolarifica ed antipiretica».Boll. Chim. Farm., 112, 529, 1973.

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Authors and Affiliations

  1. Endoscopic Center, Milan Polyclinic, Milano

    E. Mirelli, G. Fichera & A. Tittobello

Authors
  1. E. Mirelli
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  2. G. Fichera
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  3. A. Tittobello
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Mirelli, E., Fichera, G. & Tittobello, A. Valuation of the anti-inflammatory activity of a new drug on the gastroduodenal and rectal mucosa. Acta Endosc 4, 149–158 (1974). https://doi.org/10.1007/BF02973579

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  • DOI: https://doi.org/10.1007/BF02973579

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