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Maximum density of tumor staining obtained by preoperative IV-DSA as a prognostic indicator for node-negative breast cancer

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Abstract

Background

We previously demonstrated that the density of tumor enhancement by intravenous digital subtraction angiography (IV-DSA) is correlated with the number of tumor microvessels and that the incidence of distant metastasis is high in patients with breast cancer who show a high maximum density of tumor enhancement (MAX) on IV-DSA. In the present study, we evaluated the prognostic value of MAX for node-negative breast cancer patients.

Patients and Methods

A total of 128 node-negative breast cancer patients underwent preoperative IV-DSA, and the region of interest (ROI) was set in the areas enhanced by IV-DSA of the breast. MAX was calculated by the time-density curve. Patients were divided into two subgroups: those with MAX ≥9 (n=35) and those with MAX <9 (n=93).

Results

Patients with recurrence had a significantly higher MAX value than those without recurrence (11.8±3.8 vs 7.1 ±3.0, p<0.01). The disease-free survival rate was significantly worse in patients with higher MAX values than in those with lower MAX values (p<0.001). Multivariate analysis showed that MAX was the strongest predictor of disease-free survival (p=0.026).

Conclusions

These results suggest that the maximum density obtained by IV-DSA is a strong, independent prognostic indicator for node-negative breast cancer patients.

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Abbreviations

IV-DSA:

Intravenous digital subtraction angiography

MAX:

Maximum density of tumor enhancement

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Authors and Affiliations

  1. Department of Surgery, Tokyo Women’s Medical University Daini Hospital, Tokyo

    Osamu Watanabe, Shunsuke Haga, Tadao Shimizu, Hiroshi Imamura, Jun Kinoshita, Hiroshi Nagumo, Yoshihito Utada, Toshihiro Okabe, Kiyomi Kimura, Akira Hirano & Tetsuro Kajiwara

Authors
  1. Osamu Watanabe
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  2. Shunsuke Haga
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  3. Tadao Shimizu
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  4. Hiroshi Imamura
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  5. Jun Kinoshita
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  6. Hiroshi Nagumo
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  7. Yoshihito Utada
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  8. Toshihiro Okabe
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  9. Kiyomi Kimura
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  10. Akira Hirano
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  11. Tetsuro Kajiwara
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Cite this article

Watanabe, O., Haga, S., Shimizu, T. et al. Maximum density of tumor staining obtained by preoperative IV-DSA as a prognostic indicator for node-negative breast cancer. Breast Cancer 6, 365–369 (1999). https://doi.org/10.1007/BF02966455

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  • DOI: https://doi.org/10.1007/BF02966455

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