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Circadian rhythm of type II 5′deiodinase activity in the rat hypothalamic-pituitary-adrenal axis

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Abstract

Type II 5′ deiodinase (5′D-II) activity was assessed in the hypothalamus (HP), pituitary (PIT), and adrenal gland (AG) of adult male rats after two different photoperiodic regimes: (1) cyclic light-dark conditions (LD, 12∶12) or (2) 4 days in continuous darkness (DD). Under cyclic LD conditions HP, PIT and AG 5′D-11 activity showed a significant circadian rhythm (P<0.004−<0.0001). The acrophases obtained by cosinor analysis were: HP, 12∶37; PIT, 03∶04 and AG, 02∶30 h. In contrast, after 4 days in DD, HP 5′D-II rhythmicity was abolished and there was a significant shift in the acrophase of both PIT and AG enzyme activity. These results suggest that the 5′D-II oscillation in PIT and AG corresponds to an endogenous circadian rhythm and is not only a response to the presence of a L/D cycle.

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Authors and Affiliations

  1. Centro de Neurobiología, Universidad Nacional Autónoma de México, Ciudad Universitaria, 04510, México, D F

    M. Luna, G. Guzmán, L. Navarro & C. Valverde-R

  2. Subjefatura de Investigación Biomédica, IMSS, México, D.F.

    S. Sánchez de la Peña

Authors
  1. M. Luna
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  2. G. Guzmán
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  3. L. Navarro
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  4. S. Sánchez de la Peña
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  5. C. Valverde-R
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Luna, M., Guzmán, G., Navarro, L. et al. Circadian rhythm of type II 5′deiodinase activity in the rat hypothalamic-pituitary-adrenal axis. Endocr 3, 597–601 (1995). https://doi.org/10.1007/BF02953025

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