Skip to main content
SpringerLink
Log in

Serum copper and zinc in industrial centers in Slovakia

  • Published:
Biological Trace Element Research Aims and scope Submit manuscript

Abstract

The association between serum copper and zinc concentrations and age, sex, and other risk factors of cardiovascular disease in randomly selected adult volunteers aged 19–59 were investigated. There was a positive relationship between copper and age in both sexes, but zinc was negatively correlated with age in males only. Serum zinc was positively related to HDL-cholesterol in males. Serum copper was positively related to total cholesterol and LDL-cholesterol but negatively correlated to HDL-cholesterol in males. A positive relationship to body mass index was observed in females only. Subjects have been divided into a control group and a group with marked risk factors of cardiovascular disease. The levels of zinc were not different, whereas the levels of copper in both males and females were significantly higher in the risk group. Our results suggested a positive relationship between serum copper and cumulation of more factors of cardiovascular disease, however, their causal effect in humans has to be investigated further.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. L. M. Klevay,Am. J. Clin. Nutr. 28, 764 (1975).

    PubMed  CAS  Google Scholar 

  2. J. T. Salonen, R. Salonen, H. Korpela, S. Suntioinen, and J. Tuomilehto,Am. J. Epidemiol. 134, 268 (1991).

    PubMed  CAS  Google Scholar 

  3. J. F. Kok, C. M. Van Duijn, A. Hofman, G. B. Van Der Voet, F. A. De Wolff, C. H. Ch. Paays, and H. A. Valkenburg,Am. J. Epidemiol. 128, 352 (1988).

    PubMed  CAS  Google Scholar 

  4. R. Laitinen, E. Vuori, J. Viikari,J. Am. Coll. Nutr. 8, 400 (1989).

    PubMed  CAS  Google Scholar 

  5. M. F. P. Lopes-Virela, S. Ellis, and J. A. Colwell,Clin. Chem. 23, 882 (1977).

    Google Scholar 

  6. W. T. Friedewald, R. I. Levy, and D. S. Fredrikson,Clin. Chem. 18, 499 (1972).

    PubMed  CAS  Google Scholar 

  7. W. H. P. Schreurs, J. A. Klosse, T. Muys, and J. P. Haesen,Intl. J. Vit. Nutr. Res. 52, 68 (1982).

    CAS  Google Scholar 

  8. S. C. Buxaderas, and R. Farre-Rovira,Rev. Esp. Fisiol. 41, 463 (1985).

    PubMed  CAS  Google Scholar 

  9. S. C. Buxaderas and R. Farre-Rovira,Rev. Esp. Fisiol. 42, 213 (1986).

    PubMed  CAS  Google Scholar 

  10. A. K. Kant, P. B. Moser-Veillon, and R. D. Reynolds,Nutr. Res. 9, 717 (1989).

    Article  CAS  Google Scholar 

  11. D. McMaster, E. McCrum, C. C. Patterson, M. McKerr, D. O'Reilly, A. E. Evans, and A. H. G. Love,Am. J. Clin. Nutr. 56, 440 (1992).

    PubMed  CAS  Google Scholar 

  12. K. Helgeland, T. Haider, and I. Ionsen,Scand. J. Clin. Lab. Invest. 42, 35 (1982).

    Article  PubMed  CAS  Google Scholar 

  13. L. M. Klevay,Am. J. Clin. Nutr. 26, 1060 (1973).

    PubMed  CAS  Google Scholar 

  14. K. Y. Lei,Nutr. Rep. Int. 15, 597 (1977).

    CAS  Google Scholar 

  15. P. W. Harvey, and K. G. D. Allen,J. Nutr. 111, 1855 (1981).

    PubMed  CAS  Google Scholar 

  16. D. B. Milne, S. T. Omaye, and W. H. Amas,Am. J. Clin. Nutr. 34, 2389 (1981).

    PubMed  CAS  Google Scholar 

  17. K. G. D. Allen and L. M. Klevay,Atherosclerosis 29, 81 (1978).

    Article  PubMed  CAS  Google Scholar 

  18. I. Kajaba,Final report (unpublished data) (1990).

  19. T. Magalova, A. Brtkova, I. Kajaba, A. Bederova, and I. Karvasova,Cs. Gastroent. Vyz. 44, 53 (1990).

    Google Scholar 

  20. V. Iyengar and J. Woittiez,Clin. Chem. 34, 474 (1988).

    PubMed  CAS  Google Scholar 

  21. A. M. Tiber, M. Sakhaii, D. Joffe, and M. V. Ratnaparkhi,Atherosclerosis 62, 105 (1986).

    Article  PubMed  CAS  Google Scholar 

  22. Y. Thuillier-Juteau, M. C. Jaudon, J. P. Clavel, J. Delattre, and A. Galli,Path. Biol. 35, 387 (1987).

    CAS  Google Scholar 

  23. P. W. F. Fischer, and M. W. Collins,Am. J. Clin. Nutr. 34, 595 (1981).

    PubMed  CAS  Google Scholar 

  24. C. Pachotikarn, D. M. Medeiros, and T. Windham,Nutr. Rep. Int. 32, 373 (1985).

    CAS  Google Scholar 

  25. P. L. Hooper, L. Visconti, P. J. Garry, and G. E. Johnson,JAMA 244, 1960 (1980).

    Article  PubMed  CAS  Google Scholar 

  26. J. Manthey, M. Stoeppler, W. Morgenstern, E. Nussel, D. Opherk, A. Weinstraut, H. Wesch, and W. Kubler,Circulation 64, 722 (1981).

    PubMed  CAS  Google Scholar 

  27. J. S. Goodwin, W. C. Hunt, P. Hooper, and P. Garr,Metabolism 34, 519 (1985).

    Article  PubMed  CAS  Google Scholar 

  28. J. T. Salonen, R. Salonen, K. Seppanen, M. Kantola, S. Suntioinen, and H. Korpela,Br. Med. J. 302, 756 (1991).

    Article  CAS  Google Scholar 

  29. G. Uza, S. Gabor, A. Kovats, R. Vlaicu, and M. Cucuianu,Biol. Trace Elem. Res. 8, 167 (1985).

    Article  CAS  Google Scholar 

  30. D. Kromhout, A. A. E. Vibowo, R. F. M. Herber, L. M. Dalderup, H. Heerdink, C. De Lezenne Coulander, and R. L. Zielhuis,Am. J. Epidemiol. 122, 378 (1985).

    PubMed  CAS  Google Scholar 

  31. M. Katya-Katya, A. Ensminger, L. Mejeen, and G. Derby,Nutr. Res. 4, 633 (1984).

    Article  CAS  Google Scholar 

  32. S. Reiser, A. Powell, C. Y. Yang, and J.J. Canary,Nutr. Rep. Int. 36, 641 (1987).

    CAS  Google Scholar 

  33. L. M. Klevay, L. Inman, L. K. Johnson, M. Lawer, J. R. Mahalko, D. B. Milne, H. C. Lukaski, W. Bolonchuk, and H. H. Sanstead,Metabolism 33, 1112 (1984).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research Institute of Nutrition, Limbova 14, 833 37, Bratislava, Slovakia

    Tatiana Magalova, Anastazia Brtkova, Alzbeta Bederova, Igor Kajaba & Ivana Puchonova

Authors
  1. Tatiana Magalova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Anastazia Brtkova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Alzbeta Bederova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Igor Kajaba
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ivana Puchonova
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Magalova, T., Brtkova, A., Bederova, A. et al. Serum copper and zinc in industrial centers in Slovakia. Biol Trace Elem Res 40, 225–235 (1994). https://doi.org/10.1007/BF02950795

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02950795

Index Entries

Search

Navigation