Summary
The PHA response of lymphocytes from lymph nodes and peripheral blood of patients with well differentiated lymphocytic lymphoma was studied over a period of time. A single control was used to provide a cross-index of these responses for the purpose of comparing the clinical state of the patients. In almost all instances the response was lower than normal. The results fail to indicate any constant relationship between PHA responsiveness of peripheral blood lymphocytes and the extent of clinical disease. It is suggested that there may be alterations in the microcirculation of lyrhphoid and other organs which determine the random accumulation of lymphocytes seen in this disease.
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Greally, J., Fortuny, I.E. & Yunis, E.J. Lymphocyte transformation in malignant lymphoma. Ir J Med Sci 142, 255–262 (1973). https://doi.org/10.1007/BF02950020
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DOI: https://doi.org/10.1007/BF02950020