References
Ahlquist, R. P. A study of adrenotropic receptors. Am. J. Physiol. 1948: 153, 586–600.
Powell, C. E. & Slater, I. H. Blocking of inhibitory adrenergic receptors by a dichloro analogue of isoproterenol. J. Pharmacol. Exp. Ther. 1958: 122, 480–488.
Brown, G. L. & Gillespie, J. S. The output of sympathetic transmitter from the spleen of the cat. J. Physiol. 1957:138, 81–102.
Starke, K. Alpha sympathomimetic inhibition of adrenergic and cholinergic transmission in the rabbit heart. Naunyn-Schmiedeberg’s Arch. Pharmacol. 1972: 274, 18–45.
Langer, S. Z. Presynaptic regulation of catecholamine release. Biochem. Pharmacol. 1974: 23, 1793–1800.
Drew, G. M. & Whiting, S. B. Evidence for two distinct types of postsynaptic α-adrenoceptor in vascular smooth muscle in vivo. Br. J. Pharmacol. 1979: 67; 207–215.
Docherty, J. R., MacDonald, A. & McGrath, J. C. Further subclassification of α-adrenoceptors in the cardiovascular system, vas deferens and anococcygeus of the rat. Br. J. Pharmacol. 1979: 67, 421P-422P.
Madjar, H., Docherty, J. R. & Starke, K. An examination of pre- and postsynaptic a-adrenoceptors in the autoperfused rabbit hindlimb. J. Cardiovasc. Pharmacol. 1980: 2, 619–627.
Schumann, H. J. & Lues, I. Postjunctional α-adrenoceptors in the isolated saphenous vein of the rabbit. Naunyn- Schmiedeberg’s Arch. Pharmacol. 1983: 323, 328–334.
Docherty, J. R. & Hyland, L. Evidence for neuro-effector transmission through postjunctional α2-adrenoceptors in human saphenous vein. Br. J. Pharmacol. 1985: 84, 573–576.
Starke, K. & Langer, S. Z. A note on terminology for presynaptic receptors. In: Presynaptic receptors, Langer, S. Z., Starke, K. & Dobocovich, M. L. (Eds) 1979: pp1–3. Oxford, Pergammon Press.
Han, C., Abel, P. W. & Minneman, K. P. αl-Adrenoceptor subtypes linked to different mechanisms for increasing intracellular Ca2+ in smooth muscle. Nature 1987:329, 333–335.
Bylund. D. B. Heterogeneity of alpha-2 adrenergic receptors. Pharmacol. Biochem. Behav. 1985: 22, 835–843.
Lomasney, J. W., Cotecchia, S., Lorenz, W., Leung, W.-Y., Schwinn, D. A., Yang-Feng, T. L., Brownstein, M., Lefkowitz, R. J. & Caron, M. G. Molecular cloning and expression of the cDNA for the α1A-adrenergic receptor. J. Biol. Chem. 1991: 266, 6365–6369.
Perez, D. M., Piascik, M. T. & Graham, R. M. Solution- phase library screening for the identification of rare clones: isolation of an α1D adrenergic receptor cDNA. Mol. Pharmacol. 1992: 40, 876–883.
Lorenz, W., Lomasney, J. W., Collins, S., Regan, J. W., Caron, M. G. & Lefkowitz, R. J. Expression of three α2- adrenergic receptor subtypes in rat tissue: Implications for α2-receptor classification. Mol. Pharmacol. 1990:38, 599–603.
Dolphin, A. C. Nucleotide binding proteins in signal transduction and disease. Trends Nuerosci. 1987: 10, 53–57.
Docherty, J. R. Pertussis toxin and prejunctional α2- adrenoreceptors in rat heart and vas deferens. J. Auton. Pharmacol. 1988: 8, 107–201.
Docherty, J. R. No effect of pertussis toxin on peripheral prejunctional α2-adrenoceptor-mediated responses and on endothelium-dependent relaxations in the rat. Br. J. Pharmacol. 1990:100, 348–352.
Allgaier, C., Feuerstein, T. J., Jackisch, R. & Hertting, G. Islet-activating protein (pertussis toxin) diminishes α2- adrenoceptor mediated effects on noradrenaline release. Naunyn-Schmiedeberg’s Arch. Pharmacol. 1985:331, 235–239.
Musgrave, I., Marley, P. & Majewski, H. Pertussis toxin does not attenuate α2-adrenoceptor mediated inhibition of noradrenaline release in mouse atria. Naunyn-Schmiedeberg’s Arch. Pharmacol. 1987: 336, 280–286.
Murphy, T. V., Foucart, S. & Majewski, H. Prejunctional α2-adrenoceptors in mouse atria function through G-proteins which are sensitive to Nethylmaleimide, but not pretussis toxin. Br. J. Pharmacol. 1992: 106, 871–876.
Gross, G., Hanft, G. & Rugevics, C. 5-Methyl-urapidil discriminates between subtypes of the α1-adrenoceptor. Eur. J. Pharmacol. 1988: 151, 333–335.
Docherty, J. R. Thepharrnacology of α1-and α2-adrenoeeptors: Evidence for and against a further subdivision. Pharmacol. Ther. 1989: 44, 241–284.
Hanft, G. & Gross, G. Subclassification of α1-adrenoceptor recognition sites by urapidil derivatives and other selective antagonists. Br. J. Pharmacol. 1989: 97, 691–700.
Cotecchia, S., Schwinn, D. A., Randall, R. R., Lefkowitz, R. J., Caron, M. G. & Kobilka, B. K. Molecular cloning and expression of the cDNA for the hamster α1-adrenergic receptor. Proc. Natl. Acad. Sci. U.S.A. 1988: 85, 7159–7163.
Voigt, M. M., Kispert, J. & Chin, H. Sequence of a rat brain cDNA encoding α1B-adrenergic receptor. NucleicAcids Res. 1990:18, 1053.
Schwinn, D. A., Lomasney, J. W., Lorenz, W., Szklut, P. J., Fremeau, R. T., Yang-Feng, T. L., Caron, M. G., Lefkowitz, R. J. & Cotecchia, S. Molecular cloning and expression of the cDNA for a novel αt-adrenergic receptor subtype. J. Biol. Chem. 1990: 265, 8183–8189.
Aboud, R., Shafii, M. & Docherty, J. R. Investigation of the subtypes of α1-adrenoceptor mediating contractions of rat aorta, vas deferens and spleen. Br, J. Pharmacol. 1993: 109, 80–84.
Mallard, N. J., Marshall, R. W., Sithers, A. J. & Spriggs, T. L. B. Separation of putative α1A- and α1B-adrenoceptor mediated components in the tension response of the rat vas deferens to electrical field stimulation, Br. J. Pharmacol. 1992: 105, 727–731.
Han, C., Li, J. & Minneman, K. P. Subtypes of α1- adrenoceptors in rat blood vessels. Eur. J. Pharmacol. 1990: 190, 97–104.
Piascik, M. T., Sparks, M. S., Pruitt, T. A. & Soltis, E. E. Evidence for a complex interaction between the subtypes of the α1-adrenoceptor. Eur. J. Pharmacol. 1991: 199, 279–289.
Muramatsu, I., Kigoshi, S. & Ohmura, T. Subtypes of α1- adrenoceptors involved in noradrenaline induced contractions of rat thoracic aorta and dog carotid artery. Japan J. Pharmacol. 1991: 57, 535–544.
Aboud, R. & Docherty, J. R. Investigations of contractions mediated by noradrenaline in rat aorta. Br. J. Pharmacol. 1992: 105, 296P.
Bylund. D. B. Subtypes of α1-and α2-adrenergic receptors. FASEB J. 1992: 6, 832–839.
Lanier, S. M., Downing, S., Duzic, E. & Homey, C. J. Isolation of rat genomic clones encoding subtypes of the α2-adrenergic receptor. J. Biol. Chem. 1991: 266, 10470–10478.
Connaughton, S., & Docherty, J. R. Functional evidence for heterogeneity of peripheral prejunctional α2-adrenoceptors. Br. J. Pharmacol. 1990: 101, 285–290.
Smith, K., Connaughton, S. & Docherty, J. R. Investigations of prejunctional α2-adrenoceptors in rat atrium, vas deferens and submandibular gland. Eur. J. Pharmacol. 1992: 211, 251–256.
Smith, K. & Docherty, J. R. Are the prejunctional α2-adrenoceptors of the rat vas deferens and submandibular gland of the α2A- or α2D-subtype? Eur. J. Pharmacol. 1992: 219, 203–210.
Peroutka, S. J. Serotonin receptor subtypes and neuropsychiatric diseases: focus on 5-HT1D and 5-HT3 receptor agents. Pharmacol. Rev. 1991: 43, 579–586.
Author information
Authors and Affiliations
Additional information
Sixteenth Conway Review Lecture
Rights and permissions
About this article
Cite this article
Docherty, J.R. Alpha-Adrenoceptors: From theoretical concept to molecular visualisation. I.J.M.S. 163, 4–8 (1994). https://doi.org/10.1007/BF02943004
Issue Date:
DOI: https://doi.org/10.1007/BF02943004