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The effects of gliclazide in diabetes : a comparison with tolbutamide

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Summary

A STUDY was carried out to examine the effect of Gliclazide on Type I insulin dependent, and Type 2 insulin independent diabetic patients. Both Gliclazide and Tolbutamide increased HDL cholesterol in Type 2 diabetic patients (1.24±0.1→;1.72±0.15 mmol/l, p< 0.05. 1.42±0.1→1.68 ± 0.1 mmol/l, p< 0.05). This improvement appeared to be independent of any improvement in diabetic control in patients on Gliclazide. Gliclazide had no effect on Type 1 diabetic patients on insulin. These results may suggest a protective mechanism for Type 2 maturity onset diabetic patients treated with a sulphonylurea drug.

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Authors and Affiliations

  1. Metabolie Unit, Adelaide Hospital, Dublin 8

    M. J. Berber & G. H. Tomkin

Authors
  1. M. J. Berber
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  2. G. H. Tomkin
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We wish to thank Miss R. Bloomgart for carrying out the HbA1 estimation.

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Berber, M.J., Tomkin, G.H. The effects of gliclazide in diabetes : a comparison with tolbutamide. Ir J Med Sci 151, 46–49 (1982). https://doi.org/10.1007/BF02940142

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  • DOI: https://doi.org/10.1007/BF02940142

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