Abstract
Objective: To observe the effect of Yishou Tiaozhi tablet(YSTZT) on lipid metabolism and aortic intimal atherosclerotic plaque coverage in rabbit model of experimental hyperlipemia and atherosclerosis.Methods: Thirty-two rabbits were randomly divided into four groups, Group A, B, C and D, 8 in each group. Forage with cholesterol and lipid plus 1.59 g/kg of YSTZT was fed to Group A every day; for Group B, 22.54 mg/kg gypenoside tablet was added to forage with cholesterol and lipid; for Group C, hyperlipid forage was given and for Group D, only ordinary forage was given. Biochemical parameters were measured and pathomorpho-logical examinations were carried out 6 weeks later.Results: (1) YSTZT obviously lowered the levels of serum total cholesterol(TC), triglyceride(TG), atherosclerotic index(AI), apoprotein(ApoB), lipoprotein [Lp(a)], oxygen-low density lipoprotein cholesterol (ox-LDL), hydroxyproline(HYP), plasma Ca2+, thromboxane B2 (TXB2), and increased the levels of serum high-density lipoprotein cholesterol(HDL-C), apoprotein A1 (Apo A1), ApoA1/ApoB, plasma 6-keto-PGFlα (P < 0.01). (2) Pathomorphological examination showed that in Group A aortic intimal atherosclerotic plaque area and arterial intima thickness were obviously reduced, smooth muscle cell hyperplasia and elastic fibers were not seen.Conclusion: YSTZT can inhibit experimental hyperlipemia and atherogenesis. It is an ideal and effective medicine in preventing and treating hyperlipemia and atherosclerosis.
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Zhong, Y., Zhu, BK. & Zheng, SF. Experimental study of Yishou Tiaozhi tablet() on inhibiting hyperlipemia and atherosclerosis) on inhibiting hyperlipemia and atherosclerosis. CJIM 7, 43–47 (2001). https://doi.org/10.1007/BF02935110
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DOI: https://doi.org/10.1007/BF02935110