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Influence of flavonoid of astragalus membranaceus’s stem and leaf on the function of cell mediated immunity in mice

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Abstract

Objective: To investigate the immune regulation of flavonoid of Astragalus membranaceus’s stem and leaf(FAM-sl).Methods: Changes of total T cell count and subsets in mice were determined by monoantibody assay before and after treatment with FAM-sl, and the lymphokine activated killer cell (LAK) activity was tested simultaneously by isotope label method.Results: FAM-sl could promote the proliferation of lymphocytes induced by ConA, raise the total T cell count and regulate the T cell subsets disturbance, and elevate the LAK activity induced by recombinant interleukin-2 (rIL-2).Conclusion: FAM-sl possesses effects of immune stimulation and immune regulation in treating immunosuppressive mice. This study provides experimental evidence for clinical application of FAM-sl.

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References

  1. Geng Cs, Xing St, Zhou Jh, et al. Study on mechnism of Astragalus membranaceus stimulating antibody production in T cell defect mice. Shanghai J Immunology 1985;5(2):69–72.

    Google Scholar 

  2. Mao Xj, Wang Jz, Wang Fl. Advances in immunological studies of Astragalus membranaceus and Radix Hedysari. J Lanzhou Medical College 1988;(1):67–71.

    Google Scholar 

  3. Wang Wy, Chang Jl, Gao J, et al. Experimental study on effects of Astragalus membranaceus on cytokine production in aged organism. Chinese J Immunology 1995;11(5):167–169.

    Google Scholar 

  4. Ma Yl, Tian Zk, Yuan Cs. Studies on chemical ingredients in Astragalus membranaceus’s stem and leaf. J Shengyang Pharmacol College 1991; (2): 121–123,136.

    Google Scholar 

  5. Lu Sh, Zhu Yz, Wu Sj. Study on flavonoids in Astragalus membranaceus Bage van mongolicus stem and leaf. Chinese Traditional and Herbal Drugs 1990; 21 (6): 249–250,265.

    CAS  Google Scholar 

  6. Jiao Y, Wen J, Zhang Ds. Effects of flavonoid in Astragalus membranaceus’s stem and leaf on immune function in mice. Informations on TCM 1997;14(5):44.

    Google Scholar 

  7. Guan Hz, Kuang Yd, Qing Hl, et al. Comparison of 4 methods of assessing interleukin-2 (IL-2). Shanghai J Immunology 1986;6(5):298–301.

    Google Scholar 

  8. Ma Zz, Ding Rr, Sheng T, et al. Detection of activity of LAK cell in mice by3H-TdR incorporation. Chinese J Immunology 1989; 5 (1): 20–21,28.

    Google Scholar 

  9. Sheng Yq, Na Ah, Yang Zj, et al. Comparison of 12 species of Astragalus membranaceus on immune function in mice. Chinese J Immunology 1989;5(2): 119–121.

    Google Scholar 

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Heilongjiang University of TCM, 150040, Harbin

    Yan Jiao

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  1. Yan Jiao
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  2. Jie Wen
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  3. Xiao-hong Yu
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  4. De-shan Zhang
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Jiao, Y., Wen, J., Yu, Xh. et al. Influence of flavonoid of astragalus membranaceus’s stem and leaf on the function of cell mediated immunity in mice. CJIM 7, 117–120 (2001). https://doi.org/10.1007/BF02935017

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  • DOI: https://doi.org/10.1007/BF02935017

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