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Nabilone and metoclopramide in the treatment of nausea and vomiting due to cisplatinum: A double blind study

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Abstract

Thirty-two patients were entered into a double blind trial of antiemetic support in patients being treated with cisplatin. Patients were allocated to receive either oral nabilone (1 mg 8 hourly) or intravenous metoclopramide (1 mg kg−1 3 hourly) in random order over 4 courses. There was no difference between the two treatments in the overall incidence or severity of vomiting, although a subgroup of patients enjoyed a substantial reduction in episodes of vomiting whilst receiving metoclopramide. Side-effects were predictable from the pharmacology of the drugs.

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Author notes

  1. R. Buckman

    Present address: Toronto Bayview Clinic, Sunnybrook Medical Centre, 2075 Bayview Avenue, M4N 3M5, Toronto, Canada

Authors and Affiliations

  1. Department of Medical Oncology, Charing Cross Hospital, W6 8RF, London

    S. M. Crawford

  2. Department of Oncology, University College Hospital, WC1, London, U.K.

    R. Buckman

Authors
  1. S. M. Crawford
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  2. R. Buckman
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Crawford, S.M., Buckman, R. Nabilone and metoclopramide in the treatment of nausea and vomiting due to cisplatinum: A double blind study. Med. Oncol. & Tumor Pharmacother. 3, 39–42 (1986). https://doi.org/10.1007/BF02934575

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  • DOI: https://doi.org/10.1007/BF02934575

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