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Effect of cistanche desertica polysaccharides on learning and memory functions and infrastructure of cerebral neurons in experimental aging mice

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Abstract

Objective

To observe the effects of Cistanche desertica polysaccharides (CDP) on the learning and memory functions and cerebral ultrastructure in experimental aging mice.

Methods

CDP was administrated intragastrically 50 or 100 mg/kg per day for 64 successive days to experimental aging model mice induced by D-galactose, then the learning and memory functions of mice were estimated by step-down test and Y-maze test; organelles of brain tissue and cerebral ultrastructure were observed by transmission electron microscope and physical strength was determined by swimming test.

Results

CDP could obviously enhance the learning and memory functions (P<0.01) and prolong the swimming time (P<0.05), decrease the number of lipofuscin and slow down the degeneration of mitochondria in neurons(P<0.05), and improve the degeneration of cerebral ultra-structure in aging mice.

Conclusion

CDP could improve the impaired physiological function and alleviate cerebral morphological change in experimental aging mice.

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Author information

Authors and Affiliations

  1. Medical and Pharmacological Institute of Yangzhou University, 225001, Jiangsu

    Yun Sun, Yang-mei Deng, De-jun Wang, Chun-feng Shen, Xiao-mei Liu & Hong-quan Zhang

Authors
  1. Yun Sun
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  2. Yang-mei Deng
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  3. De-jun Wang
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  4. Chun-feng Shen
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  5. Xiao-mei Liu
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  6. Hong-quan Zhang
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Corresponding author

Correspondence to Yun Sun.

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Sun, Y., Deng, Ym., Wang, Dj. et al. Effect of cistanche desertica polysaccharides on learning and memory functions and infrastructure of cerebral neurons in experimental aging mice. CJIM 7, 288–292 (2001). https://doi.org/10.1007/BF02934374

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  • DOI: https://doi.org/10.1007/BF02934374

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