Abstract
Objective
To observe the effects of Fuzheng Kangbai Granule (FZKBG) on immune function and survival time in minimal residual leukemia (MRL) model mice and explore its mechanism.
Methods
MRL model mice were established by hypodermic inoculation with L7212 cells 1×106 following intraperitoneal injection of cytoxan (CTX) 250 mg/kg 3 days later, and divided into the control group and FZKBG treated group. The changes of T-lymphocyte subsets, including CD3 +, CD4 + and CD8 +, and the survival time in model mice were observed.
Results
Compared with the control, FZKBG could obviously increase both the percentage and absolute value of CD3 + and CD4 + lymphocytes and prolong the survival time of model mice, the prolongation rate being 29. 6% – 60. 4%.
Conclusion
FZKBG could markedly prolong the survival time of MRL mice, and its mechanism might be through elevating the immunologic function and inhibiting the leukemia cells in model mice.
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This study was supported by State Administration of TCM (No. 922153); and won the 3rd grade Award of 1998’ Scientific and Technological Advancement of China Academy of TCM
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Xu, Yg., Ma, R., Hu, Np. et al. Effect of fuzheng kangbai granule on immune function and survival time in minimal residual leukemia model mice. CJIM 7, 283–287 (2001). https://doi.org/10.1007/BF02934372
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DOI: https://doi.org/10.1007/BF02934372