Clinical study on epidural injected lappaconitine for post-operative analgesia

Abstract

This paper studied the effect and side-effect of epidural injected Lappaconitine (LC) for postoperative analgesia. 50 patients who were operated in the upper abdomen with epidural anesthesia, were randomly divided into 5 groups. The general condition of each group was similar. Group A, B, C was given LC 4mg, 8mg, 12mg respectively for observation. Group D,E was given 0.9% NS 6ml and morphine 2mg individually as control. When the operation was finished, LC was injected into the epidural space with single blind method. The result showed the analgesia of LC and its effective time was: group E>C>B>A>D. The analgesic effect of group C was satisfactory. The efficacy and the maintenance time of A, B, C groups were significantly different from that of group D(P<0.05, P<0.01). Although the effect of group C was less potent than that of group E (morphine injection), there was no side-effect like that of morphine. It suggested that epidural injected LC for post-operative analgesia is effective and safe.