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Biocompatibility of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolyesters produced byAlcaligenes sp. MT-16

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Abstract

Poly(3-hydroxybutyrate-co-3-hydroxyvalerate), poly(3HB-co-3HV), copolyesters, with 3-hydroxyvalerate (3HV) contents ranging from 17 to 60 mol%, were produced byAlcaligenes sp. MT-16, and their biocompatibility evaluated by the growth of Chinese hamster ovary (CHO) cells and the adsorption of blood proteins and platelets onto their film surfaces. The number of CHO cells that adhered to and grew on these films was higher with increasing 3HV content. In contrast, the tendency for blood proteins and platelets to adhere to the copolyester surfaces significantly decreased with increasing 3HV content. Examination of the surface morphology using atomic force microscopy revealed that the surface roughness was an important factor in determining the biocompatibility of theses copolyesters. The results obtained in this study suggest that poly(3HB-co-3HV) copolyesters, with >30 mol% 3HV, may be useful in biocompatible biomedical applications.

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Authors and Affiliations

  1. Department of Microbiology, Chungnam National University, 305-764, Daejeon, Korea

    Gang Guk Choi, Hyung Woo Kim & Young Ha Rhee

  2. Institute of Biotechnology, Chungnam, National University, 305-764, Daejeon, Korea

    Hyung Woo Kim

  3. Department of Polymer Materials, PaiChai University, 302-735, Daejeon, Korea

    Young Baek Kim

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  1. Gang Guk Choi
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  2. Hyung Woo Kim
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  3. Young Baek Kim
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  4. Young Ha Rhee
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Correspondence to Young Ha Rhee.

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Choi, G.G., Kim, H.W., Kim, Y.B. et al. Biocompatibility of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolyesters produced byAlcaligenes sp. MT-16. Biotechnol. Bioprocess Eng. 10, 540–545 (2005). https://doi.org/10.1007/BF02932291

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  • DOI: https://doi.org/10.1007/BF02932291

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