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Hydroxylation of progesterone by someTrichoderma species

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Abstract

Thirty-three isolates belonging to six species of the genusTrichoderma were tested for the ability to hydroxylate progesterone to 11α-, 11β-, 11α,17α- and 6β,17α-derivatives, and epicortisol.T. aureoviride, T. harzianum, T. polysporum andT. pseudokoningii produced 11α-hydroxyprogesterone.T. harzianum andT. hamatum can form only the 11β-isomer.T. koningii andT. hamatum produced 11α-,11β-, 11α,17α- and 6β,11α-hydroxy derivatives. 11α, 11β, 6β,11α- and 11α,17α-hydroxyprogesterones and epicortisol are produced byT. aureoviride andT. pseudokoningii. Cortisol was produced only when the medium was fortified by 10 g/L peptone. This is the first record of conversion of progesterone to mono-, di- and trihydroxyprogesterones by theseTrichoderma species.

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  1. Department of Botany, Faculty of Science, Assiut University, Assiut, Egypt

    I. A. El-Kadi & M. Eman Mostafa

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  1. I. A. El-Kadi
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  2. M. Eman Mostafa
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El-Kadi, I.A., Eman Mostafa, M. Hydroxylation of progesterone by someTrichoderma species. Folia Microbiol 49, 285–290 (2004). https://doi.org/10.1007/BF02931044

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