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The effect of some inhibitors on streptomycin biosynthesis

Воздействие на неко то рые ингибиторы биосинт еза стреп томицина

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Summary

The addition of atebrin (2 × 10−4M to 4 × 10−4M) or of 2,4-dinitrophenol (2 × 10−4M) to the fermentation medium ofStreptomyces griseus LS-1 at the outset of cultivation resulted in a marked decrease in the biosynthesis of streptomycin. Inhibition of production of the antibiotic was partly abolished by the addition of diethylbarbituric acid (1.35 × 10−2M). The results are discussed from the aspect of the probable relation of the biosynthesis of streptomycin to the function of flavin enzymes and to phosphorylation processes, and a hypothetical explanation of the action of diethylbarbituric acid is submitted.

Abstract

Добавить atebrin (2 × 10−4M to 4 × 10−4M) or of 2,4-dinitrophenol (2 × 10−4M)для брожения средыStreptomyces griseus LS-1Вначале культивирования при в ело к заметному сни жен ие биосинтеза стрептом ицина Ингиб ирование пр оизводства антибио тик был частично отм енена добавлением кислоты diethylbarbituric(1.35 × 10−2M).Результаты об суждаются с аспектом ве роятной связь биос инте за стрептомицин а на фун кция flavin ферментов и фо сф орилирования процесс ов и гипотетических ра зъяснением действий diethylbarbituric кислоты, представ ле нный.

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Authors and Affiliations

  1. Antibiotics Research Institute, Roztoky near Praha

    M. Musílková

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  1. M. Musílková
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Musílková, M. The effect of some inhibitors on streptomycin biosynthesis. Folia Microbiol 4, 76–81 (1959). https://doi.org/10.1007/BF02928531

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