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Effect of scarlet fever toxin on the phagocytic activity of the reticuloendothelial system

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Abstract

In normal rabbits and mice, one i.v. injection of scarlet fever toxin (ET) (30 000 STD per kg of rabbit weight or 20-g mouse) elicited a similar biphasic change in carbon clearance rate — early depression followed by a stimulating phase — as has been described for Gram-negative endotoxins. Prolonged depression without a subsequent stimulation phase was obtained in mice by raising the ET dose. The reasons of the discrepancy between these findings and those of Hanna and Watson (1965b) are discussed. Pyrogenic tolerance to ET is not accompanied by accelerated carbon clearance and is not impaired by RES blockade. A possible mechanism of ET tolerance is suggested.

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Authors and Affiliations

  1. Institute of Hygiene and Epidemiology, 10042, Prague 10

    V. Hříbalová

  2. Head of Department of Mathematical Statistics and Programming, Institute of Hygiene and Epidemiology, Prague

    Z. Both

  3. Institute of Hygiene and Epidemiology, Prague

    F. Zahradník

Authors
  1. V. Hříbalová
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  2. Z. Both
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  3. F. Zahradník
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Additional information

Preliminary results were presented at the Symposium on Toxic Products of Bacteria, Liblice (Czechoslovakia), September 12–14, 1973 (J.Hyg.Epidemiol.Microbiol.Immunol. 18, 297, 1974).

Part II of the seriesThe pathophysiological effect of scarlet fever toxin. Part I:Folia Microbiol. 13, 106 (1968).

The author wishes to thank Mrs L. Lonská for statistical analysis and Mrs M. Splítková and S. Ticháčková for technical assistance.

The author is indebted to Ing. Z. Roth, Head of Department of Mathematical Statistics and Programming, Institute of Hygiene and Epidemiology, Prague, for elaborating the mathematical model.

The iseclectric focusing was kindly performed by Dr. F. Zahradnik, Institute of Hygiene and Epidemiology, Prague.

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Hříbalová, V., Both, Z. & Zahradník, F. Effect of scarlet fever toxin on the phagocytic activity of the reticuloendothelial system. Folia Microbiol 24, 415–427 (1979). https://doi.org/10.1007/BF02927125

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  • DOI: https://doi.org/10.1007/BF02927125

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