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Mechanisms of action of alcohol administration on the trophic effect of soybean trypsin inhibitor and cholecystokinin octapeptide in rat

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Summary

Influence of alcohol administration on the trophic effect of choiecystokinin-octapeptide and soybean trypsin inhibitor administration was examined in male Wistar rats. Two x 4 mL of 20% alcohol given intragastrically during 2 wk did not significantly influence pancreatic weight, DNA, protein, trypsin, chymotrypsin, amylase, lipase, or trypsin inhibitor contents of the pancreas. It diminished the hypertrophy but not the hyperplasia seen after CCK-8 treatment, and eliminated the hyperplasia, as well as the hypertrophy provoked by SBTI administration. Secretory studies and CCK measurements demonstrated decreased CCK release in response to SBTI stimulation after 3-d alcohol administration. The results indicate that alcohol inhibits the enzyme synthesis of the CCK stimulated dividing and/or newly formed acinar cells and the endogenous CCK release.

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Authors and Affiliations

  1. 1st Department of Medicine, Albert Szent-Györgyi Medical University, PO Box 469, H-6701, Szeged, Hungary

    Á Pap, I. Nagy, T. Takács, F. Hajnal & V. Varró

  2. Department of Medical Chemistry, Albert Szent-Györgyi Medical University, PO Box 469, H-6701, Szeged, Hungary

    G. Tóth

Authors
  1. Á Pap
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  2. I. Nagy
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  3. T. Takács
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  4. F. Hajnal
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  5. G. Tóth
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  6. V. Varró
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Pap, Á., Nagy, I., Takács, T. et al. Mechanisms of action of alcohol administration on the trophic effect of soybean trypsin inhibitor and cholecystokinin octapeptide in rat. Int J Pancreatol 5, 263–272 (1989). https://doi.org/10.1007/BF02924471

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  • DOI: https://doi.org/10.1007/BF02924471

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