Skip to main content
SpringerLink
Log in

The pancreas and oxygen consumption 1

Pancreatic oxygen consumption in normo- and hypovolemic dogs

  • Published:
International journal of pancreatology Aims and scope Submit manuscript

Summary

Pancreatic oxygen consumption (VO2) was studied in hypovolemic shock: 4 dogs served as controls and 4 others were kept at 50 mm Hg of mean arterial blood pressure. All 8 were studied for a period of 3 h. Pancreatic VO2 was obtained by adding up VO2 for the head (minus the uncinate process) and tail of the pancreas both equal to the product of regional blood flow times O2 extraction. Regional blood flows were measured electromagnetically on the gastroduodenal (GDA) and the splenic (SA) arteries, whereas O2 extraction was derived from total hemoglobin (THb) and oxygen saturation of hemoglobin (%O2 Hb) determined on the right femoral artery (RFA), the superior pancreaticoduodenal (SPDV), and splenic (SV) veins. A splenectomy was performed in all 8 dogs. Controls showed a significantly elevated pancreatic VO2 from the first hour of observation on( + 56% after 1 h, + 92% after 3), whereas pancreatic VO2 remained strictly unchanged throughout shock (+ 2% and +6%, at one and 3 h, respectively), despite significant increases in O2 extraction. These findings give support to the deleterious effects of hypovolemia to the pancreas and that pancreatic O2 extraction indicates metabolic damage to be less severe than observed in experimental bile-trypsin-induced acute pancreatitis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Donaldson LA, Schenk WG Jr. Experimental acute pancreatitis. The changes in pancreatic oxygen consumption and the effect of Dextran 40. Ann. Surg. 1980; 192: 728–731.

    Google Scholar 

  2. Knol JA, Edgcomb LP, Inman MG, Eckhauser FE. Low molecular weight dextran in experimental pancreatitis: effects on pancreatic microcirculation. J. Surg. Res. 1983; 35: 73–82.

    Article  PubMed  CAS  Google Scholar 

  3. Eckhauser FE, Knol JA, Inman MG, Strodel WE. Efficacy of pharmacologic glucagon in acute experimental pancreatitis. Arch. Surg. 1985; 120: 355–360.

    PubMed  CAS  Google Scholar 

  4. Popper HL, Necheles H, Russell KC. Transition of pancreatic edema into pancreatic necrosis. Surg. Gynecol. Obstet. 1948; 87: 79–82.

    PubMed  CAS  Google Scholar 

  5. Pfeffer RB, Lazzarini-Robertson A, Safadi D, Mixter G Jr, Secoy CF, Hinton JW. Gradations of pancreatitis, edematous through hemorrhagic, experimentally produced by controlled injection of microspheres into blood vessels in the dog. Surgery 1962; 51: 764–769.

    PubMed  CAS  Google Scholar 

  6. Goodhead B. Vascular factors in the pathogenesis of acute hemorrhagic pancreatitis. Ann. R. Coll. Surg. Engl. 1969; 45: 80–97.

    PubMed  CAS  Google Scholar 

  7. Nemeth EP, Fodor I, Folly G, Papp M. Arterial hypotension as a factor aggravating the histological damage in experimental acute hemorrhagic pancreatitis, Acta Morphologica Academiae Scientiarum Hungaricae 1973; 21: 319–332.

    Google Scholar 

  8. Feiner H. Pancreatitis after cardiac surgery. A morphologic study. Am. J. Surg. 1976; 131: 684–688.

    Article  PubMed  CAS  Google Scholar 

  9. Warshaw AL, O’Hara PJ. Susceptibility of the pancreas to ischemic injury in shock. Ann. Surg. 1978; 188: 197–201.

    PubMed  CAS  Google Scholar 

  10. Hegewald G, Nikulin A, Gmaz-Nikulin E, Plamenac P, Barenwald G Ultrastructural changes of the human pancreas in acute shock. Path. Res. Pract. 1985; 179: 610–615.

    PubMed  CAS  Google Scholar 

  11. Dreiling DA, Koller M, Su CH. Vascular pancreatitis: a neglected disorder. Mt. Sinai. J. Med. 1986; 53: 492–444.

    Google Scholar 

  12. Papp M. Blood flow to the pancreas in pancreatitis. In: The pathophysiology of the splanchnic circulation. Volume II, chapter 10. Kvietys PR, Granger DN, Barrowman JA (eds). CRC Press, Boca Raton, FL, 1987.

    Google Scholar 

  13. Dreiling, DA, Robert JH, Toledano AE. Vascular pancreatitis: a clinical entity of growing importance. Clin. Gastroenterol. Submitted for publication.

  14. Beijer HJM, Maas AHJ, Charbon GA. Pancreatic O2 consumption and CO2 output during secretin-induced exocrine secretion from the pancreas in the anesthestized dog. Pflugers Arch. 1984; 400: 318–323.

    Article  PubMed  CAS  Google Scholar 

  15. Kwan MR, Hunt TK. Continuous tissue oxygen tension measurements during acute blood loss. J. Surg. Res. 1973; 14: 420–425.

    Article  PubMed  CAS  Google Scholar 

  16. Harper SL, Pitts VH, Granger DN, Kvietys PR. Pancreatic tissue oxygenation during secretory stimulation. Am. J. Physiol. 1986; 250(13): G316-G322.

    PubMed  CAS  Google Scholar 

  17. Hunt TK, Rabkin J, Jensen A, Jonsson K, von Smitten K, Goodson WH. Tissue oximetry: an interim report. World J. Surg. 1987; 11: 126–132.

    Article  PubMed  CAS  Google Scholar 

  18. Di Carlo V, Nespoli A, Chiesa R, Staudacher, C, Cristallo M, Bevilacqua G, Staudacher V. Hemodynamic and metabolic impairment in acute pancreatitis. World J. Surg. 1981; 5: 329–339.

    Article  PubMed  Google Scholar 

  19. Imrie CW, Ferguson JC, Murphy D, Blumgart LH. Arterial hypoxia in acute pancreatitis. Br. J. Surg. 1977; 64: 185–188.

    Article  PubMed  CAS  Google Scholar 

  20. Eicheiter P, Schenk WG. The influence of hypothermia on pancreatic secretion and blood flow with observations on pancreatic oxygen consumption. Arch. Surg. 1968; 96: 883–886.

    Google Scholar 

  21. Kreuzer W, Schenk WG. Hemodynamic effects of vasodilatation in “critical” arterial stenosis. Arch. Surg. 1971; 103: 177–182.

    Google Scholar 

  22. Meyer W, Castelfranchi PL, Schultz LS, Ruiz OJ, Hendrickx J, Acquino CJ, Lillehei RC. Physiologic studies during perfusion of the isolated canine pancreas. Eur. Surg. Res. 1973; 5: 105–115.

    Article  PubMed  CAS  Google Scholar 

  23. Kvietys PR, Granger DN. Relation between intestinal blood flow and oxygen uptake. Am. J. Physiol. 1982; 242(5): G202-G208.

    PubMed  CAS  Google Scholar 

  24. Kvietys PR, McLendon JM, Bulkley GB, Perry MA, Granger DN. Pancreatic circulation: intrinsic regulation. Am. J. Physiol. 1982; 242(5): G596-G602.

    PubMed  CAS  Google Scholar 

  25. Kvietys PR, Granger DN. Vasoactive agents and splanchnic oxygen uptake. Am. J. Physiol. 1982; 243(6): G1-G9.

    PubMed  CAS  Google Scholar 

  26. Cantarow A, Schepartz B. Biochemistry. In “Respiration”. 3rd edition. WB Saunders Co., Philadelphia 1961. 296–306.

    Google Scholar 

  27. Beijer HJM, Maas AHJ, Charbon GA. A vasopressin-induced decrease in pancreatic blood flow and in pancreatic exocrine secretion in the anesthetized dog. Pflugers Arch. 1984; 400: 324–328.

    Article  PubMed  CAS  Google Scholar 

  28. Studley JGN, Mathie RT, Blumgart LH. An evaluation of blood flow and perfusion in the canine pancreas. Acta Chir. Scand. 1985; 151: 551–556.

    PubMed  CAS  Google Scholar 

  29. Beijer HJM, Charbon GA, Woerlee M. Control of O2 supply to the pancreas during a cholecystokinin-induced increase in metabolism. Adv. Exp. Med. Biol. 1986; 200: 413- 417.

    PubMed  CAS  Google Scholar 

  30. Beijer HJM, Charbon GA, Woerlee M. Control of O2 supply to the pancreas during a vasopressin-induced vasoconstriction. Adv. Exp. Med. Biol. 1986; 200: 419–424.

    PubMed  CAS  Google Scholar 

  31. Fischer U, Hommel H, Schmid E. Continuous registration of the pancreatic blood flow after intravenous application of glucose. Experientia 1973; 29: 884–885.

    Article  PubMed  CAS  Google Scholar 

  32. Frogge JD, Hermreck AS, Thal AP. Metabolic and hemodynamic effects of secretin and pancreozymin on the pancreas. Surgey 1970; 68: 498–502.

    CAS  Google Scholar 

  33. Eloy MR, Kachelhoffer J, Pousse A, Dauchel J, Grenier JF. Ex vivo vascular perfusion of the isolated canine pancreas. Experimental procedure, hemodynamic data and experimental applications. Eur. Surg. Res. 1974; 6: 341–353.

    Article  PubMed  CAS  Google Scholar 

  34. Gooszen HG, van Schlifgaarde R, Terpstra JL. Arterial blood supply of the left lobe of the canine pancreas. II. Electromagnetic flow measurements. Surgery 1983; 93: 549–563. D54.

    PubMed  CAS  Google Scholar 

  35. Kim JP, Byrne JJ. Segmental venous drainage of the canine pancreas. J. Surg. Res. 1971; 11: 559–562.

    Article  PubMed  CAS  Google Scholar 

  36. Benjamin E, Paluch TA, Berger SR, Premus G, Wu C, Iberti TJ, Venous hypercarbia in canine hemorrhagic shock. Critical Care Medicine 1987; 15: 516–518.

    Article  PubMed  CAS  Google Scholar 

  37. Holst JJ, Densen SL, Nielsen OV, Schwartz TW. Oxygen supply, oxygen consumption, and endocrine and exocrine secretions of the isolated, perfused, porcine pancreas. Acta Physiol. Scand. 1980; 109: 7–13.

    Article  PubMed  CAS  Google Scholar 

  38. Nelimarkka O, Niinikoski J. Oxygen and carbon dioxyde tensions in the canine kidney during arterial occlusion and hemorrhagic hypotension. Surg. Gynecol. Obstet. 1984; 158: 27–32.

    PubMed  CAS  Google Scholar 

  39. Alteveer RJ, Jaffe MJ, Van Dam J. Hemodynamics and metabolism of the in vivo vascularly isolated canine pancreas. Am. J. Physiol. 1979; 236(6): E626-E632.

    PubMed  CAS  Google Scholar 

  40. Pascal JP, Roux P, Vaysse N, Lacroix A, Martinel C, Ribert A. Respiratory exchanges and acid-base balance during perfusion of ex vivo isolated pancreas. Dig. Dis. 1976; 21: 381–8.

    CAS  Google Scholar 

  41. Donaldson LA, Williams RW, Schenk WG Jr. Experimental pancreatitis: effect of plasma and dextran on pancreatic blood flow. Surgery 1978; 84: 313–321.

    PubMed  CAS  Google Scholar 

  42. Donaldson LA, Schenk WG Jr. Experimental acute pancreatitis. Ann. Surg. 1980; 192: 728–731.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Pancreatic Research Laboratory, Mount Sinai School of Medicine of the City University of New York, 10029, New York, NY

    John H. Robert, Aholeab E. Toledano, Gang Huang, Lewis S. Toth, Giuliano Premus & David A. Dreiling

  2. The Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary

    Miklos Papp

Authors
  1. John H. Robert
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Aholeab E. Toledano
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Gang Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Lewis S. Toth
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Giuliano Premus
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Miklos Papp
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. David A. Dreiling
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Robert, J.H., Toledano, A.E., Huang, G. et al. The pancreas and oxygen consumption 1. Int J Pancreatol 4, 51–63 (1989). https://doi.org/10.1007/BF02924147

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02924147

Key Words

Search

Navigation