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Tissue oximetry: An interim report

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Abstract

Tissue oximetry, already a practical reality in some centers, holds considerable promise for clinical use. It has the capacity to monitor the oxygen delivery system and estimate perfusion of tissues; and we suspect it can add considerably to prevention of surgical complications and treatment of surgical infections. Present instruments are relatively difficult to use, but their potential is not being utilized largely because of misconceptions about the transport of oxygen in tissue and the significance of peripheral perfusion. Oximetry measures perfusion, whereas currently popular indices such as urine output are indirect indicators and are often misleading.

The basic concepts of tissue oxygenation, the relevance of partial pressure of oxygen in tissue, the connection with perfusion, various technologies for measuring tissue oxygenation, and the currently available methods are discussed.

Résumé

L'oxymétrie tissulaire déjà employée dans quelques centres est porteuse de promesses considérables sur le plan de la clinique. La méthode possède la capacité de monitorer la distribution de l'oxygène et d'apprécier la perfusion des tissus. Pour les auteurs de l'article, elle est susceptible également de constituer un appoint considérable pour prévenir l'apparition des complications chirurgicales et pour traiter les infections chirurgicales. Les instruments actuels sont d'un emploi relativement difficile, mais leur potentiel n'a pas été assez utilisé en raison de conceptions inexactes concernant le transport de l'oxygène dans les tissus et l'importance de la perfusion périphérique. L'oxymétrie permet de mesurer directement la perfusion périphérique alors que les indices couramment utilisés, tel que le débit urinaire, ne sont que des indications indirectes conduisant souvent à des erreurs.

Fort de ces faits, les auteurs de l'article passent en revue les concepts de base de l'oxygénation tissulaire, la valeur de la pression partielle de l'oxygène tissulaire, la connexion avec la perfusion, les différentes techniques de mesure de l'oxygénation tissulaire et les méthodes actuellement disponibles.

Resumen

La oximetría tisular, la cual ya es una realidad práctica en algunos centros médicos, aparece como promisoria para el uso clínico. Posee la capacidad de monitoría del sistema de provisión tisular de oxígeno y de estimar la perfusión de los tejidos; se espera que pueda contribuir en forma considerable a la prevención de las complicaciones quirúrgicas y al tratamiento de las infecciones en cirugía. Los instrumentos actuales son de difícil uso, pero su potencial no ha sido utilizado en razón, principalmente, de las concepciones erróneas que existen sobre el transporte del oxígeno en los tejidos y el significado de la perfusión periférica. La oximetría mide la perfusión tisular, mientras algunos índices de uso común, tal como el volumen urinario, son sólo indicadores indirectos y con frecuencia engañosos.

En este trabajo se discuten los conceptos básicos de oxigenación, la pertinencia de la presión parcial de oxígeno en los tejidos, la relación con la perfusión, las diversas tecnologías para medir oxigenación tisular, y los métodos actualmente disponibles.

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References

  1. Hutton, J.J., Jr., Tappel, A.L., Udenfriend, S.: Cofactor and substrate requirements of collagen proline hydroxylase. Arch. Biochem. Biophys.118:231, 1967.

    Google Scholar 

  2. Hunt, T.K., Niinikoski, J., Zederfeldt, B.H., Silver, I.A.: Oxygen in wound healing enhancement: Cellular effects of oxygen. In Hyperbaric Oxygen Therapy, J.C. Davis, T.K. Hunt, editors, Bethesda, Undersea Medical Society, Inc., 1977, pp. 111–122

    Google Scholar 

  3. Hohn, D.C., Mackay, R.D., Halliday, B.J., Hunt, T.K.: Effect of O2 tension on microbicidal function of leukocytes in wounds and in vitro. Surg. Forum27:18, 1976

    Google Scholar 

  4. Hunt, T.K., Pai, M.P.: The effect of varying oxygen ambient oxygen tensions on wound metabolism and collagen synthesis. Surg. Gynecol. Obstet.135:561, 1972

    Google Scholar 

  5. Niinikoski, J.: Effect of oxygen supply on wound healing and formation of experimental granulation tissue. Acta Physiol. Scand. [Suppl.]334:1, 1969

    Google Scholar 

  6. Medawar, P.B.: The behaviour of mammalian skin epithelium under strictly anaerobic conditions. O.J.M.S.89:27, 1948

    Google Scholar 

  7. Pai, M.P., Hunt, T.K.: Effect of varying oxygen tensions on healing of open wounds. Surg. Gynecol. Obstet.135:756, 1972

    Google Scholar 

  8. Perrins, D.J.D.: Influence of hyperbaric oxygen on the survival of split-thickness skin grafts. Lancet1:868, 1967.

    Google Scholar 

  9. Niinikoski, J.: Oxygen and wound healing. Clin. Plast. Surg.4:361, 1977

    Google Scholar 

  10. Knighton, D.R., Halliday, B., Hunt, T.K.: Oxygen as an antibiotic: A comparison of the effects of inspired oxygen concentration and antibiotic administration on in vivo bacterial clearance. Arch. Surg.121:191, 1986.

    Google Scholar 

  11. Piasecki, C.: First experimental results with the oxygen electrode as a local blood flow sensor in canine colon. Br. J. Surg.72:452, 1985

    Google Scholar 

  12. Nelimarkka, O., Halkola, L., Niinikoski, J.: Effect of graded hemorrhage on renal cortical perfusion in dogs. Am. J. Surg.141:235, 1981

    Google Scholar 

  13. Peterson, J.I., Fitzgerald, R.V.: Fiber-optic probe for in vivo measurement of oxygen partial pressure. Anal. Chem.56:62, 1984

    Google Scholar 

  14. Kreisman, N.R., Sick, T.J., Rosenthal, M.: Importance of vascular responses in determining cortical oxygenation during recurrent paroxysmal events of varying duration and frequency of repetition. J. Cereb. Blood Flow Metab. [Suppl.]3:330, 1983.

    Google Scholar 

  15. Sheldon, C.A., Cerra, F.B., Bohnhoff, N., Belani, K., Frieswyk, D., Dhanalal, K., Leonard, A.S.: Peripheral postcapillary venous pressure: A new, more sensitive monitor of effective blood volume during hemorrhagic shock and resuscitation. Surgery94:399, 1983

    Google Scholar 

  16. Podolsky, S., Baraff, L.J., Geehr, E.: Transcutaneous oxymetry measurements during acute blood loss. Ann. Emerg. Med.11:523, 1982

    Google Scholar 

  17. Kram, H.B., Shoemaker, W.C.: Method for intraoperative assessment of organ perfusion and viability using a miniature oxygen sensor. Am. J. Surg.148:404, 1984

    Google Scholar 

  18. Harward, R.S., Volny, J., Golbranson, F., Bernstein, E.F., Fronek, A.: Oxygen inhalation-induced transcutaneous PO2 changes as a predictor of amputation level. J. Vasc. Surg.2:220, 1985

    Google Scholar 

  19. Abraham, E., Oye, R.K., Smith, M.: Detection of blood volume deficits through conjunctival oxygen tension monitoring. Crit. Care Med.12:931, 1984

    Google Scholar 

  20. Kwan, M.R., Hunt, T.K.: Continuous tissue oxygen tension measurements during acute blood loss. J. Surg. Res.14:420, 1973

    Google Scholar 

  21. Kwan, M.R., Fatt, J.A.: A noninvasive method of continuous arterial oxygen tension estimation from measured palpebral conjunctival oxygen tension. Anesthesiology55:309, 1971

    Google Scholar 

  22. Gottrup, F., Firmin, R., Chang, N., Goodson, W.H., III, Hunt, T.K.: A new method for clinical and experimental measurement of tissue oxygen tension. Am. J. Surg.146:399, 1983

    Google Scholar 

  23. Chang, N., Goodson, W.H., III, Gottrup, F., Hunt, T.K.: Direct measurement of wound and tissue oxygen tension in postoperative patients. Ann. Surg.197:470, 1983

    Google Scholar 

  24. Jensen, J.A., Goodson, W.H., III, Vasconez, L., Knighton, D.R., Hunt, T.K.: Wound healing in anemia: A case report. West. J. Med. (in press)

  25. Kessler, M., Gormandt, L., Lang, H.: Correlation between oxygen tension in tissue and hemoglobin dissociation curve. In Oxygen Supply. Theoretical and Practical Aspects of Oxygen Supply and Microcirculation of Tissue, M. Kessler, D.F. Bruley, L.C. Clark, Jr., editors, Baltimore, University Park Press, 1973, pp. 156–159

    Google Scholar 

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Supported by NIGMS GM27345.

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Hunt, T.K., Rabkin, J., Jensen, J.A. et al. Tissue oximetry: An interim report. World J. Surg. 11, 126–132 (1987). https://doi.org/10.1007/BF01656394

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