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Magnetic resonance appearance of the kidneys in paroxysmal nocturnal hemoglobinuria

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Urologic radiology

Abstract

A diagnosis of paroxysmal nocturnal hemoglobinuria may be suggested with magnetic resonance imaging, based on the massive renal cortical hemosiderosis that occurs in this disease. A diffuse bilateral depression of renal cortical signal intensity will be observed that is caused mainly by a shortening of the T2 relaxation time of renal cortical protons by the paramagnetic effect of the locally increased ferric ion concentration in the proximal convoluted tubule.

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References

  1. Braren V, Butler SA, Hartmann RC, Jenkins DE: Urologic manifestations of paroxysmal nocturnal hemoglobinuria.J Urol 114:430–434, 1975

    CAS  PubMed  Google Scholar 

  2. Clark DA, Butler SA, Braren V, Hartmann RC, Jenkins DE: The kidneys in paroxysmal nocturnal hemoglobinuria.Blood 57(1):83–89, 1981

    CAS  PubMed  Google Scholar 

  3. Hartmann RC, Jenkins DE, McKee LC, Heysell RM: Paroxysmal nocturnal hemoglobinuria: clinical and laboratory studies relating to iron metabolism and therapy with androgen and iron.Medicine 45:331–363, 1966

    Article  CAS  PubMed  Google Scholar 

  4. Runge VM, Clanton JA, Smith FW, Partain L, James AE: Nuclear magnetic resonance of iron and copper disease states.AJR 141:943–948, 1983

    CAS  PubMed  Google Scholar 

  5. Stark DD, Moseley ME, Bacon BR, Moss AA, Goldberg HI, Bass NM, James T: Magnetic resonance imaging and spectroscopy of hepatic iron overload.Radiology 154:137–142, 1985

    CAS  PubMed  Google Scholar 

  6. Lande IM, Glazer GM, Sarnaik S, Aisen A, Rucknagle D, Martel W: Sickle cell nephropathy: MR imaging.Radiology 158:379–384, 1986

    CAS  PubMed  Google Scholar 

  7. Wintrobe MM, Lee GR, Boggs DR, Bithell TC, Athens JW, Foerster J:Clinical Hematology, 6th ed. London: Lea and Febiger, 1974, p 163

    Google Scholar 

  8. Leung AWL, Bydder GM, Steiner RE, Bryant DJ, Young IR: Magnetic resonance imaging of the kidneys.AJR 143:1215–1227, 1984

    CAS  PubMed  Google Scholar 

  9. Hricak H, Crooks L, Sheldon P, Kaufman L: Nuclear magnetic resonance imaging of the kidney.Radiology 146:425–432, 1983

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Diagnostic Radiology, Allegheny General Hospital, 320 East North Avenue, 15212, Pittsburgh, PA, USA

    Anthony R. Lupetin M.D.

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  1. Anthony R. Lupetin M.D.
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Lupetin, A.R. Magnetic resonance appearance of the kidneys in paroxysmal nocturnal hemoglobinuria. Urol Radiol 8, 101–103 (1986). https://doi.org/10.1007/BF02924088

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  • DOI: https://doi.org/10.1007/BF02924088

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