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A critical review and evaluation of bioproduction of organic chemicals

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Abstract

Dependence on petroleum as the primary feedstock for production of chemicals cannot continue indefinitely. Bioconversion could provide an alternate route to production of organic chemicals. A wide range of commodity chemicals and potentially new chemicals can be produced via bioconversion of biomass. However, before large-scale bioproduction of organic chemicals becomes a reality, issues related to economics, feedstock availability, environment, and energy requirements must be addressed. In this paper, these issues are discussed. and promising potential candidates for bioproduction are identified. Research needs are briefly addressed.

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References

  1. Lynd, L. R. (1989),Adv. Biochem. Eng./Biotechnol. 38, 2–52.

    Google Scholar 

  2. Annual Energy Outlook 1990 (January 1990), DOE/EIA-0383(90), Government Printing Office (202-783-3238), GPO Stock No. 061-003-00649-3.

  3. National Energy Policy Plan Projections (1985), US Department of Energy, Office of Planning and Analysis, Available from National Technical Information Center (NTIS; Springfield, VA), DOE/PE-0029/3.

  4. Ng, T. K., Busche, R. M., McDonald, C. C, and Hardy, R. W. F. (February 11, 1983),Science 219, 733–740.

    Article  CAS  Google Scholar 

  5. Lipinsky, E. S. (1981),Science 212, 1465–1471.

    Article  CAS  Google Scholar 

  6. Palsson, B. O., Fathi-Afshar, S., Rudd, D. F., and Lightfoot, E. N. (1981),Science 213, 513–517.

    Article  CAS  Google Scholar 

  7. Best, D. J. (1985),Molecular Biology and Biotechnology, Walker, J. M. and Gingold, E. B., eds., The Royal Society of Chemistry, London, pp. 228–267.

    Google Scholar 

  8. Busche, R. M. (1985),Biotechnol. Prog. 1 (3), 165–180.

    Google Scholar 

  9. Ringpfeil, M. and Prause, M. (1986),Chimicaoggi 11, 86–90.

    Google Scholar 

  10. Boyles, D. T. (1986),J. Chem. Tech. Biotechnol. 36, 495–511.

    CAS  Google Scholar 

  11. Stiefel, E. I. (1987),Chem. Eng. Prog. 83 (10), 21–34.

    CAS  Google Scholar 

  12. Jimenez, A. and Chavez, O. (1988),Chem. Eng. J. 37 (1), B1-B15.

    Article  CAS  Google Scholar 

  13. Toussaint, P. and Bataille, P. (1989),Int. Chem. Eng. 29 (4), 627–645.

    Google Scholar 

  14. Busche, R. M. (1989),Appl. Biochem. Biotechnol. 20/21, 655–674.

    Article  Google Scholar 

  15. Parisi, F. (1989),Adv. Biochem. Eng./Biotechnol. 38, 53–87.

    CAS  Google Scholar 

  16. Leeper, S. A. and Andrews, G. F. (1991),Production of Organic Chemicals via Bioconversion: A Review of the Potential, DOE Report No. EGG-BG-9033.

  17. Anonymous, (1989), Facts and Figures for the Chemical Industry,Chem. Eng. News 67 (25), 36.

  18. Bouchard, E. F. and Merritt E. G. (1978),Kirk-Othmer Encyclopedia of Chemical Technology, 3rd Ed., vol. 6, John Wiley, New York, pp. 150–179.

    Google Scholar 

  19. Overend, R. P. (1989),Energy Stud. Rev. 1 (1), 16–27.

    Google Scholar 

  20. Dimmling, W. and Nesemann, G. (1985),CRC Crit. Rev. Biotechnol. 2 (3), 233–285.

    Article  CAS  Google Scholar 

  21. Lockeretz, W., Shearer, G., and Kohl, D.H. (1981),Science 211, 540–547.

    Article  CAS  Google Scholar 

  22. Reganold, J. P., Elliott, L. F., and Unger, Y. L. (1987),Nature 330 (6146), 370–372.

    Article  Google Scholar 

  23. Reganold, J. P., Papendick, R. I., and Parr, J. F. (1990),Sci. Am. 262, pp. 112–120.

    Google Scholar 

  24. Chambers, R. S., Herendeen, R. A., Joyce, J. J., and Penner, P. S. (1979),Science 206 (4420), 789–795.

    Article  Google Scholar 

  25. Anonymous, (1989),Chem. Marketing Reporter 236 (26), 26–34.

  26. Lipinsky, E. S. (1986),Chem. Eng. Prog. 82 (8), 26–32.

    CAS  Google Scholar 

  27. Kern, J. C. (1980),Kirk-Othmer Encyclopedia of Chemical Technology, 3rd Ed., vol. 11, John Wiley, New York, pp. 921–932.

    Google Scholar 

  28. Dawes, E. A. (1988),Biomass Rep. 8 (6), 537–547.

    Article  CAS  Google Scholar 

  29. Griffin, M. and Magor, A. M. (1986),Biotechnol. Genet. Eng. Rev. 4, 263–290.

    CAS  Google Scholar 

  30. Atkinson, B. and Mavituna, F. (1983),Biochemical Engineering and Biotechnology Handbook, Nature, New York.

    Google Scholar 

  31. Anonymous, (1986),Chem. Eng. News 64 (23), 22.

  32. Nemec, J. W. and Bauer, W. Jr. (1978),Kirk-Othmer Encycl. Chem. Tech., 3rd Ed., vol. 1, John Wiley, New York, pp. 330–354.

    Google Scholar 

  33. Morrison, R. T. and Boyd, R. N. (1966),Organic Chemistry, 2nd Ed., Allyn and Bacon, Boston, MA.

    Google Scholar 

  34. Milsom, P. E. and Meers, J. L. (1985),Comprehensive Biotechnology vol. 3(The Practice of Biotechnology: Current Commodity Products), Moo-Young, M. et al, eds., Pergamon, New York, pp. 665–680.

    Google Scholar 

  35. Office of Technology Assessment (January 1984),Commercial Biotechnology: An International Analysis, US Government Printing Office Report No. OTA- BA-218, US Congress, Washington, DC.

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Authors and Affiliations

  1. Idaho National Engineering Laboratory, EG&G Idaho, Inc., Biotechnology, Bioprocess Engineering, 83415, Idaho Falls, ID

    Stephen A. Leeper & Graham F. Andrews

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  1. Stephen A. Leeper
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  2. Graham F. Andrews
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Leeper, S.A., Andrews, G.F. A critical review and evaluation of bioproduction of organic chemicals. Appl Biochem Biotechnol 28, 499–511 (1991). https://doi.org/10.1007/BF02922629

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  • DOI: https://doi.org/10.1007/BF02922629

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