Abstract
Immobilization ofRhizopus arrhizus mycelium improved fumaric acid production. The optimum conditions for fumaric acid production with immobilized cells were investigated using a statistical experimental design. Substrate concentration, carbon:nitrogen ratio, and residence time were chosen as independent variables. In the repeated batch shake flask fermentation, the fumaric acid yield from xylose was as much as 3.5 times higher with immobilized mycelium than with free mycelium. Polyurethane foam cubes, in this case, gave better results than nylon net cubes as a carrier.
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Kautola, H., Linko, YY. Production of fumaric acid with immobilized biocatalysts. Appl Biochem Biotechnol 24, 161–170 (1990). https://doi.org/10.1007/BF02920242
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DOI: https://doi.org/10.1007/BF02920242