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Expression of IL-5 receptors on B cells: Role in mucosal B cell responses

  • B Cell Differentiation
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Summary

IL-5 plays an important role in mucosal B cell responses. An in vitro model of IgA B cell differentiation, CH12LX, has been used to demonstrate that IL-5R are expressed on both IgM+ and IgA+ B cells and that IL-5 will enhance secretion of both IgM and IgA by CH12LX B cells, depending on the surface isotype of individual cells. Further, the enhanced secretion of Ig in response to IL-5 is associated with increased steady-state levels of Ig mRNA. Finally, normal Peyer's patch B cells are also capable of expressing IL-5R in response to appropriate stimuli (i.e. anti-IgM- or anti-IgD-dextran). Thus, mucosal B cell responses to IL-5 are brought about by interaction of IL-5 with specific receptors expressed on the surface of those cells.

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Authors and Affiliations

  1. Mucosal Immunity Section, Laboratory of Clinical Investigation National Institute of Allergy and Infectious Diseases, National Institutes of Health, 20892, Bethesda, MD, (USA)

    Gregory R. Harriman, Kirsi C. Allison & Warren Strober

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  1. Gregory R. Harriman
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  2. Kirsi C. Allison
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  3. Warren Strober
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Harriman, G.R., Allison, K.C. & Strober, W. Expression of IL-5 receptors on B cells: Role in mucosal B cell responses. Immunol Res 10, 413–417 (1991). https://doi.org/10.1007/BF02919733

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  • DOI: https://doi.org/10.1007/BF02919733

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