Abstract
The effects of copper deficiency on the fatty acid composition of mitochondrial and microsomal phospholipids in rat liver were studied. Copper deficiency was induced by a milk powder diet. To evaluate the effect of the milk diet on the fatty acid pattern of mitochondrial and microsomal phospholipids, one group of rats was fed Cusupplemented powdered milk. A decrease in the relative proportion of linoleic acid and an increase in the level of oleic and docosahexaenoic acids in membrane phospholipids were found in this group. However, no changes in the fatty acid pattern characteristic of essential fatty acid deficiency were observed. Dietary copper deficiency produced a significant decrease in the relative amounts of linoleic and arachidonic acids, as well as an increase in the docosahexaenoic acid content in both mitochondrial and microsomal membranes compared to the nondeficient controls. The disproportionate quantities of polyunsaturated fatty acids are discussed with a view to the disturbances of membrane function in copper deficiency.
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Balevska, P.S., Russanov, E.M. & Stanchev, P.I. Copper deficiency-induced changes in the fatty acid composition of mitochondrial and microsomal membranes of rat liver. Biol Trace Elem Res 8, 211–218 (1985). https://doi.org/10.1007/BF02917460
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DOI: https://doi.org/10.1007/BF02917460
Index Entries
- Copper deficiency and fatty acid membrane composition
- milk diet, and Cu-adequate diet
- effect of Cu-supplemented milk diet on fatty acid composition of liver mitochondrial and microsomal membranes
- mitochondrial membranes, Cu-deficiency-induced changes in fatty acid composition of
- microsomal membranes, Cu-deficiency-induced changes in fatty acid composition of mono-unsaturated: saturated ratios for C16 and C18 fatty acids in microsomes, which are indicative of the efficiency of desaturase reaction in vivo