Abstract
Aspergillus carbonarius and a strain ofPenicillium, a cadmium tolerant fungi, are able to metabolize cadmium chloride up to 2% (w/v). Their amino acids analysis on cadmium free and cadmium chloride containing media indicated certain disorders in their metabolic activities. Cystathionine was only detected in both fungi in the presence of cadmium chloride. However, cadmium was incorporated into several types of low and high molecular weight proteins. The amino acids hydrolyzates of a cadmium containing protein are characterized by the presence of high levels of sulfur amino acids; cysteine and methionine. Ethylasparagine was detected in the hydrolyzate of that cadmium containing protein as well.
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References
M. Margoshes and B. L. Vallee,J. Am. Chem. Soc. 79, 4813–4814 (1957).
J. H. R. Kagi and L. L. Vallee,J. Biol. Chem. 235, 3460–3465 (1960).
J. H. R. Kagi and G. L. Vallee,J. Biol. Chem. 236, 2435–2442 (1961).
P. Pulido, J. H. R. Kagi, and B. L. Vallee,Biochem. 5, 1768–1776 (1966).
R. H. O. Buhler and J. H. R. Kagi,FEBS Lett. 39, 229–234 (1974).
M. Piscator,Nord. Hyg. Tidskr 45, 76–82 (1964).
G. Nordberg, M. Nordberg, M. Piscator, and O. Vesterberg,Biochem. J. 126, 491–498 (1972).
M. Nordberg, B. Trojanowska, and G. Nordberg,Environ. Physiol. Biochem. 5, 396–403 (1974).
J. H. R. Kagi, S. R. Himmelhoch, P. Whanger, J. Bethune, and B. L. Vallee,J. Biol. Chem. 249, 3537–3542 (1974).
Y. Kojima, C. Berger, B. L. Vallee and J. H. R. Kagi,Proc. Natl. Acad. Sci. USA 73, 3413–3417 (1976).
F. N. Kotsonis and C. D. Klassen,Toxicol Appl. Pharmacol. 41, 667–680 (1977).
S. E. Ramadan, A. A. Razak, and H. G. Soliman,Biol. Trace. Element Res. 18, 179–190 (1988).
R. L. Bieleski and N. A. Turner,Anal. Biochem. 17, 278–298 (1966).
S. E. Ramadan, A. A. Razak, A. M. Ragab, and M. El-Meleigy,Biol. Trace. Element Res. 20, (3) 225–232 (1989).
O. H. Lowry, N. J. Rosebrough, A. L. Furr, and R. J. Randell,J. Biol. Chem. 193, 265–275 (1951).
B. L. Davis,Ann. NY Acad. Sci. 121, 404–427 (1964).
A. I. VogelA Textbook of Quantitative Inorganic Analysis Including Elementary Instrumental Analysis, 3rd ed., Longmans, Green and Co. Ltd., 1961, pp. 800–801.
S. E. Ramadan, Ph.D. thesis, University of London (1980).
D. A. Bender,Amino Acid Metabolism, J. Wiley, 1978, p. 59.
G. Rotilio,Metalloproteins, U. Weser ed., Verlag Stuttgart, New York, 1979, pp. 1–81.
M. Nordberg and Y. Kojina,Metallothionein, J. H. R. Kagi and M. Nordberg ed., Birkhauser, Basle, 1979, pp. 41–124.
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Razak, A.A. Incorporation of cadmium into proteins in a cadmium tolerant fungi. Biol Trace Elem Res 22, 277–285 (1989). https://doi.org/10.1007/BF02916616
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DOI: https://doi.org/10.1007/BF02916616