Abstract
Background Recent data indicate an exponential increase in proton pump inhibitor (PPI) prescribing, and concerns are raised regarding the appropriateness of these prescriptions and the financial implications.
Aim To survey the appropriateness of PPI prescription in a cohort of patients in a tertiary referral hospital.
Methods Prescription records of all inpatients on a randomly selected day were reviewed. The appropriateness of prescription and relevant investigations were identified by interview of patients, review of patient records and of a computerised endoscopy records system.
Results Thirty-two per cent (87 of 272) of all patients were on PPIs. A valid indication for therapy was not apparent in 63% of the patients on PPIs with the only predictive factor for inappropriate prescription being increasing age. Only 36 of the 87 patients on PPIs had undergone appropriate investigations for their gastrointestinal symptoms. Gender, age, speciality of admission or duration of hospital stay did not influence the appropriateness of prescription or performance of relevant investigations.
Conclusion There appears to be a widespread and inappropriate use of PPIs in hospital practice.
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References
Garner A, Fadlallah H, Parson ME. 1976 and all that! 20 years of antisecretory therapy.Gut 1996; 39: 784–6.
Eriksson S, Lanstrom G, Rinker L et al. Omeprazole and H2- receptor antagonists in the acute treatment of duodenal ulcer, gastric ulcer and reflux esophagitis: a meta-analysis.Eur J Gastroenterol Hepatol 1995; 7 (5): 465–75.
Freemantle N, Johnson R, Dennis J et al. Sleeping with the enemy? A randomised controlled trial of a collaborative health authority/industry intervention to influence prescribing practice.Br J Clin Pharmacol 2000; 49: 174–9.
Stricland-Hodge B, Jepson MH. The role of hospital consultant in general practice prescribing.J R Soc Med 1988; 81: 207–9.
Bashford JN, Norwood J, Chapman SR. Why are patients prescribed proton pump inhibitors ? Retrospective analysis of link between morbidity and prescribing in the General Practice Research Database.BMJ 1998; 317: 452–6.
Svoboda AC. Increasing concerns about chronic proton pump inhibitor use.J Clin Gastroenterol 2001; 33 (1): 3–10.
Brandhagen DJ, Phaley AM, Onstad GR et al. Omeprazole use at an urban county teaching hospital.J Gen Intern Med 1995; 109: 513–5.
Bramble MG, Suvakovic Z, Hungin APS. Detection of upper gastrointestinal cancer in patients taking antisecretory therapy prior to gastroscopy.Gut 2000; 46: 464–7.
Cooper AL, Longworthy H, Porter S. Cost-effective prescribing of proton pump inhibitor therapy: an audit in general practice.Int J of Clin Practice 2000; 54 (5): 287–92
Rubin GP, Contractor B, Bramble MG. The use of long-term acid suppression therapy.B J Clin Pract 1995; 49 (3): 119–20.
Gregoire JP, Moisan J, Chabot I et al. Appropriateness of omeprazole prescribing in Quebec’s senior population.Can J Gastroenterol 2000; 14 (8): 676–80.
Bateman DN. Proton pump inhibitors: three of a kind?Lancet 1997; 349: 1637–8.
Harris AW, Beveridge IG, Dove-Edwin I et al. Audit of use of antisecretory drugs.GUT 1997; 40 (suppl 1): A59.
Jones MI, Greenfield SM, Jowet S et al. Proton pump inhibitors: a study of GPs prescribing.Family Practice 2001; 18: 333–8.
Pillans PI, Kubler PA, Radford JM et al. Concordance between use of proton pump inhibitors and prescribing guidelines.Med J Aust 200; 172: 16–8.
Bevridge IG, O’Brien S, Sherman DIN. Proton pump inhibitors in hospital practice: NICE or NOT.GUT 2001; 48 (suppl 1): A35.
Brandhagen DJ, Phaley AM, Onstad GR et al. Omeprazole use at an urban county teaching hospital.J Gen Intern Med 1995; 109: 513–5.
Newton M, Smith G, Burnham WR et al. Hospital use of proton pump inhibitors: a completed audit of the introduction of a prescribing protocol on in-patient prescriptions.Gastroenterology 1998; 114 4:2: A30.
Clarke F, Meekson L, Heading RC. An audit of long-term PPI prescribing for GORD in general practice.GUT 1996; 36 (suppl 1): A36.
William M, Pounder RE. An audit of proton pump inhibitor usage in a teaching hospital setting.GUT 1997; 40 (Suppl 1): A59.
Wong TC, Danglee CA, Chan D et al. Synergistic interaction between hypergastrinemia and helicobacter infection in a mouse model of gastric cancer.Gastroenterology 2000; 118: 36–47.
Hastings LA, Bell GP, Powel KU et al. Impact of Helicobacter pylori eradication on the prescribing of ulcer healing drugs in the treatment of peptic ulcer disease in general practice.Brit J Med Econ 1997; 11: 45–53.
Prescription Pricing Authority of United Kingdom and Wales. PPA annual report 1999-2000.
Kumana CR, Ching TY, Cheung E et al. Antiulcer prescribing in hospital successfully influenced by immediate concurrent feedback.Clin Pharmacol Ther 1998; 64 (5): 569–74.
Smith DM, Cox MR, Brizendine MS et al. An intervention on discharge polypharmacy.J Am Geriatr Soc 1996; 44: 416–9.
Lesar TS, Briceland LL. Survey of antibiotic control policies in university-affiliated teaching institutions.Ann Pharmacother 1996; 30: 31–4.
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Sebastian, S., Kernan, N., Qasim, A. et al. Appropriateness of gastric antisecretory therapy in hospital practice. Ir J Med Sci 172, 115–117 (2003). https://doi.org/10.1007/BF02914494
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DOI: https://doi.org/10.1007/BF02914494