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IVIG therapy in neonatal isoimmune thrombocytopenic purpura and alloimmunization thrombocytopenia

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Abstract

IVIG is a valuable therapeutic intervention in a broad spectrum of disorders, including the treatment of the alloimmunized patient. IVIG appears to be well tolerated in the pregnant woman and the fetus. Although potential risks associated with IVIG therapy include transmission of infectious agents and allergic reactions, the vast clinical experience to date suggests that these are infrequent complications. The high cost of therapy remains a potential draw-back. Current data support the continued use of IVIG in the antenatal and postnatal treatment of isoimmune neonatal thrombocytopenia. IVIG may be useful in the treatment of platelet alloimmunization in the platelet-transfusion-dependent patient with one marrow failure and clinical hemorrhage, but in this situation responses to IVIG are varied, often transient, and methods to predict efficacy are not currently available.

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Authors and Affiliations

  1. Department of Pediatrics, Division of Hematology and Oncology, Duke University Medical Center, 27710, Durham, NC

    Joanne Kurtzherg & Kimberly P. Dunsmore

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  1. Joanne Kurtzherg
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  2. Kimberly P. Dunsmore
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Kurtzherg, J., Dunsmore, K.P. IVIG therapy in neonatal isoimmune thrombocytopenic purpura and alloimmunization thrombocytopenia. Clinical Reviews in Allergy 10, 73–80 (1992). https://doi.org/10.1007/BF02914371

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