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Nutmeg as a narcotic

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Conclusion

The seeds and arils ofM. fragmns have powerful narcotic properties. In man, they have frequently caused serious but almost never fatal intoxications. Most Westerners are ignorant of these toxic properties and know nutmeg and mace only as flavoring agents.

Both spices are used as narcotics, probably by significant numbers of people, although information on this use of Myristica is scarce. When taken deliberately as psychotropics, nutmeg and mace often cause reactions quite unlike those described in classical accounts of Myristica poisoning and much more like typical hallucinogenic drug experiences.

Thorough investigations of the history, sociology, and biochemistry of Myristica narcosis would be valuable from many points of view.

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References

  1. Huxley, Aldous. The Doors of Perception, New York: 1954.

  2. Ferguson, A. M., and J. Ferguson, All About Spices, Colombo, Ceylon:1889.

  3. Ridley, Henry N. Spices, London: 1912.

  4. Warburg, O. Die Muskatnuss, Leipzig: 1897.

  5. de Ebulo, Petrus. Carmen de motibus siculis ca. 1195.

  6. Masudi, Les Praires d’Or, 9th Century, (published at Paria in translation by Barbier and Meynard).

  7. Redgrove, H. Stanley. Spices and Condiments, London: 1933.

  8. Cardullo’s Delicatessen, Cambridge, Mass.

  9. John Wagner & Sons, spice dealers: label on container of nutmeg.

  10. Guenther, E. The Essential Oils, 1952.

  11. John Wagner & Sons, spice dealers: label on container of ground mace.

  12. Power, F. B., and A. H. Salway. The constituents of the fixed oil of nutmeg. Jour. Chem. Soc.93:1653–1659, 1908.

    CAS  Google Scholar 

  13. The Pharmacopoeia of the United States of America. XV, Easton, Pa., 1955.

  14. Power, F. B., and A. H. Salway. The constituents of the essential oil of nutmeg. Jour. Chem. Soc.91: 2037–2058. 1907.

    CAS  Google Scholar 

  15. Bamford, F. Poisons, 3rd rev. ed., Philadelphia: 1951.

  16. Shulgin, Alexander T. The possible implication of myristicin as a psychotropic substance. Unpublished paper, October, 1964.

  17. Shulgin, Alexander T. Composition of the myristicin fraction from oil of nutmeg. Nature197:4865, January 26, 1963, p. 379.

    Article  Google Scholar 

  18. Ainslie, W. Materia Indica, London: 1826.

  19. Zaitschek, David V. School of Pharmacy, Hebrew University, Jerusalem, quoted by Asaph Goor, Ministry of Agriculture of the State of Israel, Jerusalem, in personal communication, January 20, 1964.

  20. von Martius, K. F. P. Beitr. z. Litteraturgesch. d. Muskatnuss u.d. Muskatbl. 1860.

  21. Dymock. Materia Medica of Western India. Bombay: 1883.

  22. Burkill, I. H. A Dictionary of the Economic Products of the Malay Peninsula, London: 1935.

  23. Dwarakanath, C. Adviser on Indigenous Medicine, Ministry of Health, Government of India; quoted by K. R. Ramanathan, Senior Scientific Officer, Council of Scientific and Industrial Research, New Delhi, personal communication, June 18, 1964.

  24. Parkinson, John. Theatrum Botanicum. London : 1640.

  25. Green, Robert C., Nutmeg poisoning. Jour. Amer. Med. Assoc.171(10): 1342–1344. 1959.

    Google Scholar 

  26. McCord, J. A., and L. P. Jervey. Nutmeg (Myristicin) poisoning. Jour. S. Carolina Med. Assoc.58(1): 436–438. 1962.

    Google Scholar 

  27. The Dispensatory of the United States of America, XXV. Philadelphia: 1955.

  28. The Wealth of India: Raw Materials, Vol. VI. New Delhi: 1962.

  29. Bontius, J. De Medicina Indorum. Leyden: 1642.

  30. Regel, K. Das mittelniederdeutsche Gothaer Arzneibuch und seine Pflanzennamen. Osterprogr. des Gymnas. Ernestin zu Gotha, 1873 (quoted in Warburg, op. cit.: 575).

  31. Cullen, William. A Treatise on the Materia Medica. London: 1789.

  32. Hanzlik, P. J. Purkinje’s pioneer self-experiments in psychopharmacology. California and Western Medicine49(1): July, 1938 and Aug., 1938.

  33. Purkinje, J. E. Einige Beitraege zur physiologischen Pharmacologie. Neue Breslauer Sammlungen aus dem Gebiete der Heilkunde1:423–443. 1829. (quoted in Hanzlik, op. cit: 141).

    Google Scholar 

  34. Endlicher. Enchiridion bot.: 421. 1841. (quoted in Warburg, op. cit.: 567).

  35. Pereira. Materia Medica, 3rd. ed., 1836. 1850 (quoted by Warburg, op. cit.: 567).

  36. Watson, G. C. Symptoms of poisoning after eating a quantity of mace. Prov. Med. Surg. Jour. January 26, 1848 (read before the Liverpool Medical Society, 1847.

  37. The Dispensatory of the United States of America, XIX. Philadelphia: 1907.

  38. Hammond, P. W. Nutmeg poisoning. Brit. Med. Jour. 1906-II: 778.

  39. Farnsworth, P. J.in Squibb, Ephemeris of Materia Medica, etc., VII, 1904: 243–244.

    Google Scholar 

  40. Dale, H. H. Note on nutmeg poisoning. Proc. Royal Med. Soc. 1908–1909-II: (discussion) 74.

  41. Beck, R. Muenchen Med. Wschr.61:878. 1914.

    Google Scholar 

  42. Alexander J. Poisoning by nutmeg. Brit. Med. Jour. 1887-I: 1085; Bartlett, B. F. Nutmeg poisoning, Brit. Med. Jour. 1911-II: 269; Bentlif, P. B., Case of poisoning by nutmeg. Brit. Med. Jour. 1889-II. 1389; Carvell, G. H., Poisononing by nutmeg. Brit. Med. Jour. 1887-I: 1317; Gibbins, K. M., Nutmeg poisoning. Brit. Med. Jour. 1909-I: 1005; Hamilton, J. Nutmeg poisoning. Brit. Med. Jour. 1906-II: 900; Johnson, J. nutmeg poisoning. Brit. Med. Jour. 1906-II: 984; Pitter, R. A. A case of nutmeg poisoning. Lancet. 1902-I: 1035; Reekie, J. S. Nutmeg poisoning. Jour. Amer. Med. Assoc.52: 62, Jan. 2, 1909; Simpson, T. G. Case of poisoning by nutmeg. Lancet 1895-I: 150; Smith, S. M. Nutmeg poisoning. Lancet 1902-I: 1798; Wilkinson, A. N. Poisoning by nutmeg. Brit. Med. Jour. 1906-I: 539; and Wilkinson, K. D. Nutmeg poisoning. Brit. Med. Jour. 1911-I: 993.

  43. Cushny, A. R. Nutmeg poisoning. Proc. Royal Soc. Med. 1908-I(3):39.

  44. Mendelsohn, G. Two cases of poisoning by nutmeg. Deutsch. Med. Wschr.33: 2001. 1907.

    Article  Google Scholar 

  45. Payne, Robert B. Nutmeg intoxication. New Eng. Jour. Med.269(1): 36–38. 1963. (Mention of this article was made a few weeks later in the “Medicine” section of TIME Magazine.)

    CAS  Google Scholar 

  46. Mitscherlich. Lehrbuch der Arzneimittellehre, 2nd. ed., 1849 (cf. Warburg, op. cit.: 568).

  47. Wallace, G. B. Contributions to Medical Research. Ann Arbor: 1903.

  48. Jurss, F. On myristicin and some closely related substances. Bericht of Schimmel and Co., Leipzig: 1904.

    Google Scholar 

  49. Power, F. B., and A. H. Salway. Chemical examination and physiological action of nutmeg. Amer. Jour. Pharm.80:563–580. 1908.

    Google Scholar 

  50. Truitt, Edward B. et al. The pharmacology of myristicin: a contribution to the psychopharmacology of nutmeg. Digest of Neurol. Psychait.29:274. 1961.

    Google Scholar 

  51. —. The pharmacology of myristicin: a contribution to the psychopharmacology of nutmeg. Jour. Neuropsychiat.2(4):205–210. 1961.

    CAS  Google Scholar 

  52. Shulgin, Alexander T. Concerning the pharmacology of nutmeg. Mind. Oct., 1963: 299–303.

  53. Schultes, Richard E. Hallucinogenic plants of the new world. Harvard Rev.1(4): 18–32. 1963.

    Google Scholar 

  54. —. A new narcotic snuff from the northwest Amazon. Bot. Mus. Leaflets, Harvard University16(9): 241–260. 1954.

    Google Scholar 

  55. Siragussioner of Narcotics, United States Bureau of Narcotics. Personal communication, April 8, 1963.

  56. Stopp, Klaus. Institut für Spezielle Botanik and Pharmakognosie der Universitaet Mainz. Personal communication, January 22, 1964.

  57. Kline, Nathan S. Director of Research, Rockland State Hospital, Orangeburg, New York. Personal communication, February 10, 1964.

  58. Setyonegoro, K. Department of Psychiatry, University of Indonesia, Djakarta, Indonesia; A. J. Kostermans, Herbarium Bogoriense, Bogor, Indonesia.

  59. Alldredge, Noah L., Deputy Assistant Director, United States Bureau of Prisons. Personal communication, April 6, 1964.

  60. Martin, William R., Director, Addiction Research Center, United States Public Health Service Hospital, Lexington, Kentucky. Personal communication, April 9, 1964.

  61. Weiss, George, Hallucinogenic and narcotic-like effects of powdered myristica (nutmeg). Psychiat. Quart.34:(1):346–356, 1960.

    Article  PubMed  CAS  Google Scholar 

  62. ---. Personal communication, April 18, 1964.

  63. Callaway, Enoch. Chief of Research, The Langley Porter Neuropsychiatric Institute, San Francisco, California. Personal communication, April 6, 1964.

  64. Andre, Sigrid. Nutmeg jag. Mississippi Mag.4(1):18. 1964.

    Google Scholar 

  65. Truitt, Edward B. et al. Evidence of monoamine oxidase inhibition by myristicin and nutmeg. Proc. Soc. Exp. Biol. Med.112(3):647–650. 1963.

    PubMed  CAS  Google Scholar 

  66. Holmstedt, Bo. Tryptamine derivatives inepená—an intoxicating snuff used by some South American Indian tribes. Arch. int. Pharmacodyn. in press. 1965.

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Thesis for Honors in Biology, Harvard University.

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Weil, A.T. Nutmeg as a narcotic. Econ Bot 19, 194–217 (1965). https://doi.org/10.1007/BF02914307

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