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Lipid peroxidation and antioxidant vitamins in urolithasis

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Abstract

The present, study was conducted to determine the level of malondialdehyde (MDA) as an index of free radial induced lipid peroxidation and antioxidant vitamins-vitamins A, vitamin C and vitamin E in 75 confirmed cases of urolithiasis. Significantly high level of MDA (p<0.001) with significantly low levels of vitamin E (p<0.001) and vitamin A (p<0.001) with no significant decrease in vitamin C (p>0.05) were observed in the plasma of urolithiasis cases as compared to normal controls. In conclusion, it appears that a role of lipid peroxidation and oxidative function exists in the pathogenesis of urolithiasis. But, the exact mechanism how this occurs remains to be elucidated.

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Authors and Affiliations

  1. Department of Urology, Regional Institute of Medical Sciences, Imphal, Manipur

    S Sekharjit Singh

  2. Department of Biochemistry, Regional Institute of Medical Sciences, Pin-795004, Imphal, Manipur

    Kato J, Alice Abraham Ruram, S Bilasini Devi, Th Ibetombi Devi & W Gyaneshwar Singh

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  1. Kato J
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  2. Alice Abraham Ruram
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  3. S Sekharjit Singh
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  4. S Bilasini Devi
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  5. Th Ibetombi Devi
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  6. W Gyaneshwar Singh
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Correspondence to W Gyaneshwar Singh.

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Kato, J., Ruram, A.A., Singh, S.S. et al. Lipid peroxidation and antioxidant vitamins in urolithasis. Indian J Clin Biochem 22, 128–130 (2007). https://doi.org/10.1007/BF02912895

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