Summary
A comparison of the effects of tetrandrine (Tet) on 7 isolated vascular strips of rabbits was made. The influence of Tet, verapamil (Ver) and phentolamine (Phen) on noradrenaline (NA) concentration-response curves was also studied. Tet inhibited the contraction evoked by high-K+ in thoracic aortic strips and more prominently in mesenteric arterial strips. Phen antagonized NA competitively, while Tet and Ver antagonized NA in a noncompetitive manner. Calcium was also antagonized by Tet and Ver noncompetitively. These findings suggest that Tet and Ver resemble each other in inducing relaxation on vascular smooth muscles, which results from their antagonism to calcium.
Similar content being viewed by others
References
Hu WS, et al. Mode of action of tetrandrine on vascular smooth muscle. J Traditional Chin Med 1983;3: 7–12.
Van Rossum JM, et al. Cumulative doseresponse curves:I. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters. Arch Int Pharmacodyn. Ther 1963;143: 299–330.
Bristow MR, et al. Effect of diazoxide verapamil calcium-mediated dose-response relationships in isolated rabbit atrium. Eur J Pharmacol 1977;45: 267–79.
Jin MW, et al. Influence of tetrandrine on positive inotropic action of isoproterenol and CaCl2 and on excitation-contraction coupling in isolated cat papillary muscles. Acta Pharmacol Sinica 1982; 3: 97–100.
Haeusler G. Differential effect of verapamil on excitation-contraction coupling in smooth muscle and on excitation-secretion coupling in adrenergic nerve terminals. J Pharmacol Exp Ther 1972;180: 672–82.
Schueman HJ, et al. Influence of papaverine, D 600, and nifedipine on the effects of noradrenaline and calcium on the isolated aorta and mesenteric artery of the rabbit. Naunyn-Schmiedeberg’s Arch Pharmacol 1975;289: 409–18.
Chen SH, Hu CJ. Action of dauricine on aortic strips. Acta Pharmacol Sinica 1982;3: 178–82.
Meisheri KD, et al. Evidence for two separate Ca++ pathways in smooth muscle plasmalemma. J Memb Biol 1981;59: 19–25.
Van Breemen C, et al. Ca2+ movements in smooth muscle. Chest1980;78: 157–65.
Van Breemen C, et al. Excitation-contraction coupling in rabbit aorta studied by the lanthanum method for measuring cellular calcium influx. Circ Res 1972; 30: 44–54.
Bolton TB, et al. Mechanisms of action of transmitters and other substances on smooth muscle. Physiol Rev 1979;59: 606–718.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wen-shu, H., Zheng-hang, Z., Chong-jia, H. et al. Effects of tetrandrine on various vascular smooth muscles. Journal of Tongji Medical University 6, 11–14 (1986). https://doi.org/10.1007/BF02911611
Issue Date:
DOI: https://doi.org/10.1007/BF02911611