Abstract
A preliminary study was conducted to compare the BrKα/RbKα peak intensity ratio in colorectal cancer (CRC) patients and healthy subjects (controls) in Isreal. Blood samples were obtained from 61 CRC patients and 124 controls. The controls represent a normal population from different areas in Israel. Three hundred microliters of wet whole blood samples were analyzed by the EDXRF method. A weighted mean of 2.45±0.38 Br/Rb ratio was obtained for CRC patients, as compared with 3.28±0.40 Br/Rb ratio for controls. The mean value for controls represents only 112 subjects, since 12 individuals of the control group suffered from some other diseases and therefore were not included for the mean value calculation in this group. The results indicate that the Br/Rb ratio in CRC patients is significantly lower (p<0.05) than in controls. No significant difference was found in Br/Rb ratio correlated to age and sex. It was not possible to draw final conclusion concerning the relationship between the Br/Rb ratio and the malignancy stage, since there was a relatively small number of cases in each stage under investigation.
Similar content being viewed by others
References
I. Lombeck, K. Kasperek, L. E. Feinendegen, and H. J. BrenerBiol. Trace Elem. Res. 2, 193–198 (1980).
P. Bratter, V. E. Negretti de Bratter, U. Rosich, and von H. B. Stockhausen, inTrace Element Analytical Chemistry in Medicine and Biology (P. Bratter and P. Schramel, eds.), vol. 4, Walter de Gruyter, Berlin, pp. 133–143 (1987).
P. Melek-Ahmadi and M. K. Adams,Gen. Pharmacol. 18, 215–217 (1987).
G. C. Gregoriadis, N. S. Apostolidis, A. N. Romanos, and T. P. Paradellis,Cancer 52, 508–519 (1983).
S. L. Rizk and H. H. Sky-Peck,Cancer Res. 44, 5390–5394 (1984).
P. Bartsch, G. Weber, G. Robaye, J. M. Delbrouck-Habaru, A. Collignon, and I. Roelandts, inTrace Element Analytical Chemistry in Medicine and Biology (P. Bratter and P. Schramel, eds.), vol. 3, Walter de Gruyter, Berlin, pp. 399–406 (1984).
P. L. Kalliomaki, P. Paakko, K. Malmqvist, J. Pallon, S. Antilla, H. Vainio, and K. Kalliomaki, inTrace Element Analytical Chemistry in Medicine and Biology (P. Bratter and P. Schramel, eds.), vol. 5, Walter de Gruyter, Berlin, pp. 453–458 (1992).
E. Selin and V. Teeyasoontranoui,Beitr. Infusionsther. 27, 86–103 (1991).
M. S. Rapaport, M. Mantel, and C. Shenberg,Med. Phys. 9(2), 194–198 (1982).
C. Shenberg, J. Gilat, and M. Mantel, inAdvances in X-ray Analysis (C. S. Barret, J. V. Gilfrich, T. C. Huang, R. Jenkins, G. J. McCarthy, P. K. Predecki, R. Ryon, and D. K. Smith, eds.), vol. 35, Plenum, New York, pp. 1175–1182 (1992).
C. Shenberg, M. Mantel, J. Gilat, S. Chaitchik, J. Stadler, and R. Alon,Research Laboratories Annual Report, Israel Atomic Energy Commission, IA-1448, pp. 145–147 (1989).
C. Shenberg, A. Klein, T. Izak-Biran, M. Mantel, and S. Chaitchik.Fifth Int. Symp on Selenium in Biology and Medicine (Nashville, TN). Abstract Book, p. 109 (1992).
C. Shenberg, M. Boazi, J. Cohen, A. Klein, M. Kojler, and A. Nyska,Biol. Trace. Elem. Res. 40, 137–140 (1994).
Manual for Staging of Cancer, 4th ed., Lippincott, Philadelphia (1992).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Shenberg, C., Spiegel, S., Chaitchik, S. et al. The distribution of BrKα/RbKα peak intensity ratio in human whole blood samples. Biol Trace Elem Res 42, 231–241 (1994). https://doi.org/10.1007/BF02911520
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02911520