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Disturbances of morphological parameters in blood of rats orally exposed to aluminum chloride

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Abstract

The aim of this work was to assess changes of morphological parameters in the blood of rats after oral (po) administration of aluminum (Al), in relation to the time and the administered dose. The experiment was performed on female Wistar rats. The animals were administered aluminum chloride (100 mg Al/kg) daily for 21 d. Morphological assays: red blood cells (RBC), hemoglobin (HGB), hematocrit (HCT), iron serum concentration (Fe), MCH, MCHC, absolute corrected reticulocyte count (ACRC), white blood cells (WBC), and platelet count (PLT) were estimated on d 3, 7, 14, and 21, both in the control group and in intoxicated rats. After wk 1 of aluminum administration we observed a decrease of RBC, HCT, HGB and serum iron concentration in the blood of rats. The increase of the platelet count was observed earlier than changes in other parameters. Investigation has proved that the exposure of rats to aluminum administered orally results in normocytic anemia.

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Authors and Affiliations

  1. Department of Toxicological Chemistry, Medical University, Muszyńskiego 1, 90-151, Łódź, Poland

    Jadwiga Chmielnicka & Marzenna Nasiadek

  2. Department of Laboratory Diagnostics High Military Medical School, Żeromskiego, Łódź, Poland

    Roman Pínkowski & Marek Paradowski

Authors
  1. Jadwiga Chmielnicka
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  2. Marzenna Nasiadek
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  3. Roman Pínkowski
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  4. Marek Paradowski
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Chmielnicka, J., Nasiadek, M., Pínkowski, R. et al. Disturbances of morphological parameters in blood of rats orally exposed to aluminum chloride. Biol Trace Elem Res 42, 191–199 (1994). https://doi.org/10.1007/BF02911516

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  • DOI: https://doi.org/10.1007/BF02911516

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