In female Wistar rats, we studied the effects of daily 20-day administration of intragastric suspension of nanosized calcium oxide on hematological indices (the counts of erythrocytes, leukocytes, platelets, hemoglobin, hematocrit, basophils, lymphocytes, monocytes, stab/segmented neutrophils, and the eosinophil-to-lymphocyte ratio) and morphometric parameters of erythrocytes (equivalent Feret’s diameter, sphericity, aspect ratio, and convexity). The study revealed significantly (up to 3.1 times) decreased levels of hemoglobin, platelets, hematocrit, averaged content of hemoglobin in erythrocyte, and platelet volume relatively to the control values. The established morphometric parameters of blood erythrocytes attested to predominance of spherocytes, which can be regarded as systemic response of the body to calcium oxide nanoparticles fraught with possible deterioration of perfusion in microvasculature and hypoxia in the tissues.
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Bovina EM, Romanov BK, Kazakov AS, Velts NYu, Zhuravleva EO, Bukatina TM, Alyautdin RN, Merkulov VA. Nanoscale therapeutic system: safety assessment features. Bezopasnost Risk Farmakoter. 2019;7(3):127-138. Russian.
Gorbunova NA, Tunieva EK. Risks and safety of using nanotechnologies of food products: a review. Teoriya Praktika Pererabotki Myasa. 2016;1(3):35-47. Russian.
Zeinalov OА, Kombarova SP, Bagrov DV, Petrosyan MA, Tolibova GH, Feofanov AV, Shaitan KV. About the influence of metal oxide nanoparticles on living organisms physiology. Obzory Klin. Farmakol. Lek. Ter. 2016;14(3):24-33. Russian.
Muravyov AV, Komlev VL, Mikhaylov PV, Akhapkina AA, Muravyov AA. Erythrocyte deformation: the role in microcirculation. Yaroslav. Ped. Vestn. 2013;3(2):93-102. Russian.
Pleskova SN, Kryukov RN, Zubkov SY, Gornostaeva EE, Boryakov AV. Changes in the architectonics and morphometric characteristics of erythocytes under the influence of magnetite nanoparticles. Cell Tissue Biol. 2018;12(2):127-134.
Prodanchuk NG, Balan GM. Nanotoxicology: State and Prospects of Research. Sovremen. Probl. Toksikol. 2009;(3-4):4-20. Russian.
Sergeeva AS, Pivovarov YuI, Babushkina IV, Dmitrieva LA. The relation of erythrocyte sphericity with membrane proteins in arterial hypertension. Ross. Kardiol. Zh. 2016;21(4):52-58. Russian.
Dimitrijevic M, Karabasil N, Boskovic M, Teodorovic V, Vasilev D, Djordjevic V, Kilibarda N, Cobanovic N. Safety aspects of nanotechnology applications in food packaging. Procedia Food Sci. 2015;5:57-60.
Miao X, Leng X, Zhang Q. The current state of nanoparticle- induced macrophage polarization and reprogramming research. Int. J. Mol. Sci. 2017;18(2). pii: E336. https://doi.org/10.3390/ijms18020336
Ramachandraiah K, Han SG, Chin KB. Nanotechnology in meat processing and packaging: potential applications — a review. Asian-Australas. J. Anim. Sci. 2015;28(2):290-302.
Rhim JW, Park HM, Ha CS. Bio-nanocomposites for food packaging applications. Prog. Polym. Sci. 2013;38:1629-1652.
Siegrist M, Cousin M.E, Kastenholz H, Wiek A. Public acceptance of nanotechnology foods and food packaging: the influence of affect and trust. Appetite. 2007;49(2):459-466.
Soares S, Sousa J, Pais A, Vitorino C. Nanomedicine: principles, properties, and regulatory issues. Front. Chem. 2018;6:360. https://doi.org/10.3389/fchem.2018.00360
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 170, No. 11, pp. 631-635, November, 2020
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Zemlyanova, M.A., Zaitseva, N.V., Ignatova, A.M. et al. Study of Hematological Parameters and Morphometric Indices of Erythrocytes in Rats Exposed to Calcium Oxide Nanoparticles. Bull Exp Biol Med 170, 665–668 (2021). https://doi.org/10.1007/s10517-021-05128-0
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DOI: https://doi.org/10.1007/s10517-021-05128-0