Summary
Gastrin release and gastric secretion in response to i.v. dimethylxanthine (2 mg/kg for 5 min followed by a 55-min infusion of 2.5 mg/kg) were studied in 25 normal subjects. Gastrin release was significantly stimulated, whereas gastric acid and pepsin secretion was inhibited. The adenylcyclase activation may, therefore, play a role in the mechanism of gastrin release. Moreover, dimethylxanthine seems to be a useful aid in studies on G-cell function in man.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Amer M. S.: Cyclic AMP and gastric secretion — Amer. J. dig. Dis.17, 945, 1972.
Amer M. S.: Cyclic AMP and gastric acid secretion — Amer. J. dig. Dis.19, 71, 1974.
Arnold R., Köbberling J., Track N. S., Creutzfeldt W.: Lowering of basal and stimulated serum immunoreactive gastrin and gastric secretion in patients with Zollinger-Ellison syndrome by somatostatin. In: 21. Symp. Dtsch. Ges. Endokrinol. München, February 26-March 1, 1975 — Acta endocr. (Kbh.) (Suppl. 193), 75, 1975.
Atuk N. O., Blaydes M. C., Westervelt F. B. Jr.,Wood J. E. Jr.: Effect of aminophylline on urinary excretion of epinephrine and norepinephrine in man — Circulation35, 745, 1967.
Bieck P. R., Oates J. A., Robison G. A., Adkins R. B.: Cyclic AMP in the regulation of gastric secretion in dogs and humans — Amer. J. Physiol.224, 158, 1973.
Bower R. H., Sode J., Lipshutz W.: Cyclic GMP and gastric acid secretion — Amer. J. dig. Dis.19, 582, 1974.
Butcher R. W., Sutherland E. W.: Adenosine-3′-5′-phosphate in biological materials. I. Preparation and properties of cyclic 3′-5′-nucleotide phosphodiesterase and the use of this enzyme to characterize adenosine-3′-5′-phosphate in human urine — J. biol. Chem.237, 1224, 1962.
Cohen M. M., Debas H. T., Holubitsky I. B., Harrison R. C.: Caffeine and pentagastrin stimulation of human gastric secretion — Gastroenterology61, 440, 1971.
Feurle G., Arnold R., Helmstädter V., Creutzfeldt W.: The effect of intravenous theophylline ethylenediamine on serum gastrin concentration in control subjects and patients with duodenal ulcers and Zollinger-Ellison syndrome — Digestion14, 227, 1976.
Fleisher N., Donald R. A., Butcher R. W.: Adenosine-3′-5′-monophosphate (cyclic AMP): a possible mediator of ACTH secretion — Clin. Res.17, 23, 1969.
Gabrys B. F., Alavi S. M., Nyhus L. M., Bombeck C. T.: Role of cyclic AMP in the release of antral gastrin — Gastroenterology64, 730, 1973.
Grossmann M. I., Roth J. A., Ivy A. C.: Pepsin secretion in response to caffeine — Gastroenterology4, 251, 1945.
Harris J. B., Nigon K., Alonso D.: Adenosine-3′-5′-monophosphate: intracellular mediator for methylxanthine stimulation of gastric secretion — Gastroenterology57, 377, 1969.
Harty R. F., Van der Vijiver J. C., McGuigan J. E.: Direct demonstration of stimulation of gastrin secretion and synthesis by antral organ culture — Gastroenterology70, 894, 1976.
Hinze H. J.: Zur Pharmakokinetik von 3′-7′-Dimethyl-1-(5-oxo-hexyl)-xanthin (BL 191) am Menschen — Arzneimittel-Forsch.22, 1492, 1972.
Jutisz M., Paloma La Liosa M.: L’adénosine-3′-5′-monophosphate cyclique, un intermédiaire probable de l’hormone hypothalamique — C.R. Acad. Sci. (Paris)268, 1636, 1969.
Krasnow S., Grossmann M. I.: Stimulation of gastric secretion in man by theophylline ethylenediamine — Proc. Soc. exp. Biol. (N.Y.)71, 335, 1949.
Levine R. A.: Effects of exogenous adenosine-3′-5′-monophosphate in man. III. Increased response and tolerance to the dibutyryl derivate — Clin. Pharmacol. Ther.11, 238, 1970.
Levine R. A., Cafferata E. S., McNally E. F.: Inhibitory effect of adenosine-3′-5′-monophosphate (3′-5′-AMP) on gastric secretion and intestinal motility in man — Clin. Res.14, 301, 1966.
Levine R. A., Cafferata E. S., McNally E. F.: Inhibitory effect of adenosine-3′-5′-monophosphate on gastric secretion and gastrointestinal motilityin vivo. In: Proceedings of the 3rd World Congress of Gastroenterology. Tokyo, 1967; vol. 1, p. 408.
Levine R. A., Oyama S., Kagan A., Glick S. M.: Stimulation of insulin and growth hormone secretion by adenosine nucleotides in primates — J. Lab. clin. Med.75, 30, 1970.
Makhlouf G. M., Schebalin M., Zfass A. M.: Mediation of antral and duodenal gastrin release by cyclic adenosine-3′-5′-monophosphate (AMP) — Gastroenterology68, 940, 1975.
Mertz D. P., Wick T.: Effect of theophylline on acid secretion of stimulated human gastric mucosa — Experientia (Basel)25, 269, 1969.
Miederer S. E., Kaess M., Stadelmann O.: Zur Frage der Gastrinfreisetzung durch Methylxanthine — Klin. Wschr.51, 42, 1973.
Raptis S., Rothenbuchner G., Schröder K. E., Birk J., Pfeiffer E. F.: Radioimmunologische Bestimmung von Gastrin im menschlichen Serum — Acta endocr. (Kbh.) (Suppl. 152), 10, 1971.
Rick W., Fritsch W. P.: Pepsin. In:Bergmeier H. U. (Ed.): Enzymatische Methoden. Verlag Chemie, Weinheim-Bergstrasse, 1970; p. 966.
Roth J. A., Ivy A. C., Atkinson A. J.: Caffeine and ‘peptic ulcer’. Relations of caffeine-containing beverages to the pathogenesis, diagnosis and management of peptic ulcer — J. Amer. med. Ass.126, 814, 1944.
Sutherland E. W., Robison G. A.: The role of cyclic AMP in the control of carbohydrate metabolism — Diabetes18, 797, 1969.
Turtle J. R., Littleton G. K., Kipnis D. M.: Stimulation of insulin secretion by theophylline — Nature (Lond.)213, 727, 1967.
Wilber J. F., Peake G. T., Utiger R. D.: Thyrotropin releasein vitro: stimulation by cyclic 3′-5′-adenosine monophosphate — Endocrinology84, 758, 1969.
Author information
Authors and Affiliations
Additional information
This study was supported byDeutsche Forschungsgemeinschaft (SFB 87, Endokrinologie), Bonn-Bad Godesberg, Bundesrepublik Deutschland.
Rights and permissions
About this article
Cite this article
Dollinger, H.C., Raptis, S., Grebe, B. et al. Gastrin release and gastric secretion induced by dimethylxanthine in man. La Ricerca Clin. Lab. 12, 417–423 (1982). https://doi.org/10.1007/BF02909427
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02909427