Conclusions
In conclusion, HDL and their subclasses constitute an entity which plays a separate and relevant role in atherogenesis. The exact role and meaning of HDL in the evolution of cardiovascular events do not appear completely known at the present time, especially due to the small number of longitudinal studies.
HDL may be studied as a mass; however, this type of analysis is not suitable for epidemiological studies. Two components of HDL (HDL-C and ApoAI) may provide substantial information. HDL-C may be easily determined with appropriate methods of analysis; its amount is however small and small differences existing between patients and controls (few milligrams in the Framingham Study) may represent an inconvenience when the sample of patients to be examined is not too large. From this point of view, ApoAI appears as a better indicator, having a larger mass and showing a clear separation between patients and controls. However, the disposable techniques of analysis could not be considered until now particularly suitable for testing large series of subjects. When some technical problems will be solved, ApoAI could be considered as the most promising and representative component of HDL to be checked and followed.
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Avogaro, P., Cazzolato, G., Bittolo-Bon, G. et al. High density lipoproteins. La Ricerca Clin. Lab. 12, 87–95 (1982). https://doi.org/10.1007/BF02909312
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DOI: https://doi.org/10.1007/BF02909312