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Effect of tumor-derived immunosuppressive factor(s) on interleukin 2 and on expression of interleukin 2 receptor

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Summary

In this paper, we have described the effects of tumor-derived immunosuppressive factor(s) (TDSF,) on interleukin 2 (IL-2) production, on IL-2 responsiveness and on the expression of IL-2 receptors. The results showed that TDSF was able to markedly inhibit the production of IL-2 from PHA-stimulated lymphocytes and IL-2-dependent proliferation of activated lymphocytes, and to partially inhibit the expression of IL-2 receptor. These results suggest that inhibiting IL-2 production and responsiveness may be a major mechanism by which TDSF inhibit T lymphocyte proliferation and other immune responses. That TDSF exerted a very potent inhibiting action on IL-2 responsiveness is especially noticeable if we consider using IL-2 as an immunotherapeudic agent. This may be an important reason why treatment of tumor with IL-2 did not yield satisfactory results so far.

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Authors and Affiliations

  1. Department of Medical Molecular Biology, Tongji Medical University, Wuhan

    Wang Ru-duan, Luo Yi, Feng Zuo-hua & Chen Zhao-cong

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  1. Wang Ru-duan
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  2. Luo Yi
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  3. Feng Zuo-hua
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  4. Chen Zhao-cong
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Ru-duan, W., Yi, L., Zuo-hua, F. et al. Effect of tumor-derived immunosuppressive factor(s) on interleukin 2 and on expression of interleukin 2 receptor. Journal of Tongji Medical University 10, 43–47 (1990). https://doi.org/10.1007/BF02909121

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