Summary
Intracytoplasmic collagen fibres contained in elongated membrane-bound structures were observed in fibroblasts of regenerating tendon in the later stages of the repair process. The observations appear to support the hypothesis that collagen fibres of the intercellular matrix may be phagocytosed by the cells and degraded in the intracellular environment. Phagocytosis of extracellular collagen fibres probably represents an additional mechanism of collagen resorption during the later stages of remodelling of the regenerating tendon.
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Allegra S. R., Broderick P. A.: Desmoid fibroblastoma. Intracytoplasmic collagenosynthesis in a peculiar fibroblastic tumor: light and ultrastructural study of a case — Hum. Path.57, 81, 1969.
Brandes D., Anton E.: Lysosomes in uterine involution: intracytoplasmic degradation of myofilaments and collagen — J. Geront.24, 55, 1969.
De Martino C., Stefanini M., Bellocci M., Quintarelli G.: Osmium tetroxide-picric acid. A new fixation technique in electron microscopy — J. submicroscop. Cytol.4, 111, 1972.
Deporter D. A., Ten Cate A. R.: Fine structural localization of acid and alkaline phosphatase in collagen-containing vesicles of fibroblasts — J. Anat. (Lond.)114, 457, 1973.
Fox H.: Tissue degeneration: an electron microscopic study of the tail skin ofRana temporaria during metamorphosis — Arch. Biol. (Liège)83, 373, 1972.
Gmelin J. A., Rossner J. A., Feist D.: Untersuchungen an Leberbiopsien bei Thalassaemia major — Verh. dtsch. Ges. Path.57, 251, 1973.
Gona A. G.: Light and electron microscopic study of thyroxine-inducedin vitro resorption of the tadpole tail fin — Z. Zellforsch. (Abt. Histochem.)95, 483, 1969.
Gronioski J., Walski M.: Electron microscopic observations on chronic aggressive hepatitis: participation of hepatocytes in liver fibrosis — Path. Europ.10, 37, 1975.
Levine A. M., Reddick R., Triche T.: Intracellular collagen fibrils in human sarcomas — Lab. Invest.39, 351, 1978.
Listgarten M. A.: Intracellular collagen fibrils in the periodontal ligament of the mouse, hamster, guinea pig and rabbit — J. periodont. Res.8, 335, 1973.
Luse S., Hutton R.: An electron microscopic study of the fate of collagen in the postpartum rat uterus — Anat. Rec.148, 108, 1964.
Parakkal P. F.: Involvement of macrophages in collagen resorption — J. Cell Biol.41, 345, 1969.
Parakkal P. F.: Role of macrophages in collagen resorption during hair growth cycle — J. ultrastruct. Res.29, 210, 1969.
Pérez-Tamayo R.: Collagen resorption in carrageenin granulomas. II. Ultrastructure of collagen resorption — Lab. Invest.22, 142, 1970.
Pérez-Tamayo R.: Collagen degradation and resorption: physiology and pathology. In:Pérez-Tamayo R., Rojikind M. (Eds): The biochemistry of disease. Molecular pathology of connective tissues. M. Dekker Inc., New York, 1973; vol. 3.
Postacchini F., Accinni L., Natali P. G., Ippolito E., De Martino C.: Regeneration of rabbit calcaneal tendon. A morphological and immunochemical study — Cell Tiss. Res.195, 81, 1978.
Renteria U. G., Ferrans V. J.: Intracellular collagen fibrils in cardiac valves of patients with the Hurler’s syndrome — Lab. Invest.34, 263, 1976.
Scherft J. P., Heersche J. N. M.: Accumulation of collagen-containing vacuoles in osteoblasts after administration of colchicine — Cell Tiss. Res.157, 353, 1975.
Seifert K.: Elektronenmikroskopische Untersuchungen am juvenilen Nasenrachenfibrom — Arch. klin. exp. Ohr.-, Nas.-, u. Kehlk.-Heilk.198, 215, 1971.
Trelstad R. L.: Vacuoles in the embryonic chick corneal epithelium, an epithelium which produces collagen — J. Cell Biol.48, 689, 1971.
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Postacchini, F., Ippolito, E., Puddu, G. et al. Intracellular collagen fibres in regenerating tendon. La Ricerca Clin. Lab. 11, 343–347 (1981). https://doi.org/10.1007/BF02909033
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DOI: https://doi.org/10.1007/BF02909033