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Human Ia-like antigens

Analysis of the tissue distribution and immunochemical profile with monoclonal antibodies

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Ricerca in clinica e in laboratorio

Summary

Analysis of the tissue distribution of human Ia-like antigens has shown that they have a wider distribution than originally reported. Furthermore, the expression of Ia-like antigens may change when cells undergo malignant transformation: for instance, melanoma cells acquire Ia-like antigens, while breast carcinoma cells lose them. Serological and immunochemical analysis of Ia-like antigens with monoclonal antibodies has shown a cellular and molecular heterogeneity of these molecules which had not been previously recognized with conventional allo- and xenoantisera. The functional significance of this heterogeneity is not known. Monoclonal antibodies to human Ia-like antigens cross-react with lymphocytes from other animal species indicating that portions of the molecules have been conserved during evolution. The biological implications of these findings are discussed.

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Authors and Affiliations

  1. Laboratorio di Immunologia, Istituto Regina Elena, Roma

    Pier Giorgio Natali

  2. Department of Molecular Immunology, Scripps Clinic and Research Foundation, La Jolla, Calif.

    Carlo Russo, Michele A. Pellegrino & Soldano Ferrone

  3. Cattedra di Patologia Generale, Facoltà di Scienze Università degli Studi di Roma, Italia

    Cinzia Apollonj

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  1. Pier Giorgio Natali
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  2. Carlo Russo
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  3. Cinzia Apollonj
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  4. Michele A. Pellegrino
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  5. Soldano Ferrone
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Additional information

This work was supported byConsiglio Nazionale delle Ricerche (CNR), Roma, Italy, Finalized CNR Project ‘Control of tumor growth’, grant no. 80.0159.96, and by the National Institutes of Health, grants AI 13154, CA 16069, CA 16071, CA 24329 and CA 29897; a Research Career Development Award (MAP) and an American Heart Association Established Investigatorship Award (SF).

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Natali, P.G., Russo, C., Apollonj, C. et al. Human Ia-like antigens. La Ricerca Clin. Lab. 11, 287–300 (1981). https://doi.org/10.1007/BF02909028

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