Abstract
Eleven of the amino terminal 14 amino acid residues have been assigned in theΒ chain of the murine I-Cd subregion molecule. The murineΒ chain shows no homology with P29 (the putative humanΒ chain equivalent), theΒ chain of guinea pig Ia. 4, 5, or the murineI-A subregion Β chain.
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Bach, F.H., Widmer, M.B., Bach, M.L., and Klein, J.: Serologically defined and lymphocyte-defined components of the major histocompatibility complex in the mouse.J. Exp. Med. 136:1420–1444, 1972
Barnstable, C.J., Jones, E.A., Bodmer, W.F., Bodmer, J.G., Arce-Gomez, B., Snary, D., and Crumpton, M.J.: Genetics and serology of HL-A-linked human Ia antigens.Cold Spring Harbor Symp. Quant. Biol. 41:443–455, 1977
Benacerraf, B., and McDevitt, H.O.: Histocompatibility-linked immune response genes.Science 1975:273–279, 1972
Cambier, J.C., Vitetta, E.S., Kettman, J.R., Wetzel, G., and Uhr, J.W.: B cell tolerance III. Effect of papain-mediated cleavage of cell surface IgD on tolerance susceptibility of murine B cells.J. Exp. Med. 146:107–117, 1977
Capra, J.D., Vitetta, E.S., Klapper, D.G., Uhr, J.W., and Klein, J.: Structural studies on protein products of murine chromosome 17: partial amino acid sequence of anH-2K b molecule.Proc. Natl. Acad. Sci. U.S.A. 73:3661–3665, 1976
Cecka, M., and Hood, L.:Third Ir-Gene Workshop. Academic Press, New York, 1977 (in press)
Cullen, S.E., Freed, J.H., and Nathenson, S.G.: Structural and serological properties of murine Ia alloantigens.Transplant. Rev. 30:236–270, 1976a
Cullen, S.E., and Schwartz, B.D.: An improved method for isolation of H-2 and Ia alloantigens using immunoprecipitation induced by protein A-bearing staphylococci.J. Immunol. 117:136–142, 1976b
Frelinger, J.A., Neiderhuber, J.E., and Shreffler, D.C.: Inhibition of immune responsesin vitro by specific antisera to Ia antigens.Science 188:268–270, 1975
Katz, D.H., and Benacerraf, B.: The function and interrelationships of T-cell receptors, Ir genes and other histocompatibility gene products.Transplant. Rev. 22:175–195, 1975
Klein, J.:Biology of the Mouse Histocompatibility-2 Complex, pp. 389–489, Springer-Verlag, New York, 1975
Laemmli, U.K.: Cleavage of structural proteins during the assembly of the head of bacteriophage T4.Nature (Lond) 227:680–685, 1970
Meo, T., David, C.S., and Shreffler, D.C.: H-2 associated MLR determinants. Immunogenetics of the loci and their products.In B. Benacerraf and D. Katz (eds.):The Role of Products of the Histocompatibility Gene Complex in Immune Responses, pp. 167–178, Academic Press, New York, 1976
Schwartz, B.D., Kask, A.M., and Shevach, E.M.: The guinea pig MHC: functional significance and structural characterization.Cold Spring Harbor Symp. Quant. Biol. 41:397–403, 1976
Schwartz, R.H., David, C.S., Sachs, D.H., and Paul, W.E.: T lymphocyte enriched murine peritoneal exudate cells III. Inhibition of antigen-induced T lymphocyte proliferation with anti-la antisera.J. Immunol. 117:531–540, 1976
Shreffler, D.C., David, C.S., Cullen, S.E., Frelinger, J.A., and Niederhuber, J.E.: Serological and functional evidence for further subdivision of theI regions of theH-2 gene complex.Cold Spring Harbor Symp. Quant. Biol. 41:477–487, 1976
Silver, J., Cecka, J.M., McMillan, M., and Hood, L.: Chemical characterization of products of theH-2 complex.Cold Spring Harbor Symp. Quant. Biol. 41:369–377, 1976
Strominger, J.L., Chess, L., Humphreys, R.E., Mann, D., Parham, P., Robb, R., Schlossman, S., Springer, T., and Terhorst, C.: Isolation and structure of products of the human histocompatibility gene complex.In B. Benacerraf and D. Katz (eds.):The Role of Products of the Histocompatibility Gene Complex in Immune Responses, pp. 621–645, Academic Press, New York, 1976
Springer, T.A., Kaufman, J.F., Terhorst, C., and Strominger, J.L.: Purification and structural characterization of human HLA-linked B-cell antigens.Nature 268:213–218, 1977
Vitetta, E.S., Capra, J.D., Klapper, D.G., Klein, J., and Uhr, J.W.: The partial amino acid sequence of an H-2K molecule.Proc. Natl. Acad. Sci. U.S.A. 73:905–909, 1976
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Cook, R., Vitetta, E.S., Capra, J.D. et al. The partial amino acid sequence of a murine Ia molecule. Immunogenetics 5, 437–443 (1977). https://doi.org/10.1007/BF01570502
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DOI: https://doi.org/10.1007/BF01570502